Novel cynomolgus macaque MHC-DPB1 polymorphisms in three South-East Asian populations*
K. Sano
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorT. Shiina
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorS. Kohara
Shin Nippon Biomedical Laboratories, Ltd, 16-1 Minamiakasaka, Kainan, Wakayama 642-0017, Japan
Search for more papers by this authorK. Yanagiya
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorK. Hosomichi
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorS. Shimizu
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorT. Anzai
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorA. Watanabe
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorK. Ogasawara
Department of Pathology, Shiga University of Medical Science, School of Medicine, Seta, Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan
Search for more papers by this authorR. Torii
Research Center for Animal Life Science, Shiga University of Medical Science, School of Medicine, Seta, Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan
Search for more papers by this authorJ. K. Kulski
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Center for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, WA 6150, Australia
Search for more papers by this authorCorresponding Author
H. Inoko
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
†Hidetoshi Inoko Department of Molecular Life Science Division of Basic Medical Science and Molecular Medicine Tokai University School of Medicine 143 Shimokasuya Isehara Kanagawa 259-1143 Japan Tel: 81 44 463 93 1121 Fax: 81 44 463 94 8884 e-mail: [email protected]Search for more papers by this authorK. Sano
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorT. Shiina
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorS. Kohara
Shin Nippon Biomedical Laboratories, Ltd, 16-1 Minamiakasaka, Kainan, Wakayama 642-0017, Japan
Search for more papers by this authorK. Yanagiya
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorK. Hosomichi
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorS. Shimizu
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorT. Anzai
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorA. Watanabe
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Search for more papers by this authorK. Ogasawara
Department of Pathology, Shiga University of Medical Science, School of Medicine, Seta, Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan
Search for more papers by this authorR. Torii
Research Center for Animal Life Science, Shiga University of Medical Science, School of Medicine, Seta, Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan
Search for more papers by this authorJ. K. Kulski
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
Center for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, WA 6150, Australia
Search for more papers by this authorCorresponding Author
H. Inoko
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan
†Hidetoshi Inoko Department of Molecular Life Science Division of Basic Medical Science and Molecular Medicine Tokai University School of Medicine 143 Shimokasuya Isehara Kanagawa 259-1143 Japan Tel: 81 44 463 93 1121 Fax: 81 44 463 94 8884 e-mail: [email protected]Search for more papers by this authorAbstract
Cynomolgus macaques (Macaca fascicularis, Mafa), alias the crab-eating monkeys or long-tailed macaques, live across a vast range of South-East Asia. These non-human primates have emerged as important animal models in infectious and chronic diseases and transplantation studies, necessitating a more extensive characterization of their major histocompatibility complex polymorphic regions. The current information on the polymorphic variation or diversity of the Mafa-DPB1 locus is largely limited in comparison with the more commonly studied rhesus macaque DPB1 locus. In this article, to better elucidate the degree and types of polymorphisms and genetic differences of Mafa-DPB1 locus among three South-East Asian populations and to investigate how the allele differences between macaques and humans might affect their respective immune responses, we identified 40 alleles within exon 2 of the Mafa-DPB1 locus by DNA sequencing using 217 individuals. We also performed evolutionary and population analyses using these sequences to reveal some population-specific alleles and trans-species allelic conservation between the cynomolgus macaques and the rhesus macaques. Of the 40 new alleles, eight belong to a newly identified lineage group not previously found in the rhesus macaque species. This allele information will be useful for medical researchers using the cynomolgus macaques in disease and immunological studies.
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