Plasma adiponectin level and sleep structures in children with Prader–Willi syndrome
EUN YEON JOO
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
The first two authors as listed contributed equally to the study.
Search for more papers by this authorSEUNG BONG HONG
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
The first two authors as listed contributed equally to the study.
Search for more papers by this authorYOUNG BAE SOHN
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorMIN JUNG KWAK
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorSU JIN KIM
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorYOUNG OK CHOI
Clinical Research Center, Samsung Biomedical Research Institute, Seoul, Korea
Search for more papers by this authorSEON WOO KIM
Clinical Research Center, Samsung Biomedical Research Institute, Seoul, Korea
Search for more papers by this authorKYUNG-HOON PAIK
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorDONG-KYU JIN
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorEUN YEON JOO
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
The first two authors as listed contributed equally to the study.
Search for more papers by this authorSEUNG BONG HONG
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
The first two authors as listed contributed equally to the study.
Search for more papers by this authorYOUNG BAE SOHN
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorMIN JUNG KWAK
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorSU JIN KIM
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorYOUNG OK CHOI
Clinical Research Center, Samsung Biomedical Research Institute, Seoul, Korea
Search for more papers by this authorSEON WOO KIM
Clinical Research Center, Samsung Biomedical Research Institute, Seoul, Korea
Search for more papers by this authorKYUNG-HOON PAIK
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorDONG-KYU JIN
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorSummary
Adiponectin, an adipose tissue-derived hormone, has been negatively related to obstructive sleep apnea syndrome. Besides sleep apnea, children with Prader–Willi syndrome (PWS) may have excessive daytime sleepiness and rapid eye movement (REM) sleep abnormality. The aim of this study is to determine whether changes in sleep structures are related to plasma adiponectin levels in PWS. Correlations between adiponectin level and sleep variables were analyzed in 28 children with PWS and 18 controls. Overnight polysomnography was performed. The fasting plasma adiponectin levels were higher in the children with PWS than in the controls (P = 0.0006). In the PWS, Epworth sleepiness scale was significantly higher (P = 0.002); sleep latency (P = 0.003) and REM latency (P = 0.001) were significantly shortened; the apnea–hypopnea index (AHI) was significantly increased (P = 0.0001); and the duration of non-rapid eye movement (NREM) sleep stages 3 and 4 was decreased (P = 0.005). Multiple regression analysis revealed correlations between the adiponectin level and the total sleep time (β = 0.688, P = 0.009), AHI (β = 1.274, P = 0.010), REM latency (β = −0.637, P = 0.021) and the percentage of NREM sleep (β = −7.648, P = 0.002) in PWS. In children with PWS, higher plasma adiponectin levels were independently associated with several sleep variables, which was not observed in the control group. These results suggest a potential influence of elevated adiponectin level on the sleep structures in PWS.
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