Volume 22, Issue 2 pp. 181-186
Original Article Clinical Investigation

Hospital admissions after transrectal ultrasound-guided biopsy of the prostate in men diagnosed with prostate cancer: A database analysis in England

Eleni Anastasiadis

Corresponding Author

Eleni Anastasiadis

Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK

Correspondence: Eleni Anastasiadis M.B.Ch.B., M.R.C.S., M.Sc., Clinical Effectiveness Unit, Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, London WC2A 3PE, UK. Email: [email protected]Search for more papers by this author
Jan van der Meulen

Jan van der Meulen

Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK

Department of Health Services Research and Policy, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK

Search for more papers by this author
Mark Emberton

Mark Emberton

Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK

Division of Surgery and Interventional Science, University College London, London, UK

Search for more papers by this author
First published: 26 September 2014
Citations: 43

Abstract

Objectives

To investigate the complication rate within 30 days after transrectal ultrasound-guided biopsy of the prostate in England, and to examine associated risk factors.

Methods

A population-based study was carried out using the English cancer registry linked to administrative hospital data. We included men aged 45 years and older diagnosed with prostate cancer between 2000 and 2008. A complication was considered to have occurred if men had been admitted to hospital as a result of urological causes (urinary tract infection/sepsis, hematuria and urinary retention) within 30 days of the transrectal ultrasound-guided biopsy of the prostate. Multivariable logistic regression was carried out to estimate odds ratios, reflecting the impact of risk factors on the complication rate.

Results

Of the 198 361 included men, 69% were aged between 65 and 84 years. The 30-day complication rate was 3.7% (1.1% for urinary tract infection/sepsis, 1.4% for hematuria and 1.3% for urinary retention). The most important risk factors were age above 85 years (odds ratio 3.85, 95% confidence interval 3.18–4.67, compared with age below 55 years) and three or more comorbidities (odds ratio 3.50, 95% confidence interval 3.17–5.87, compared with no comorbidity). The overall complication rate increased over time (odds ratio 1.20, 95% confidence interval 1.08–1.34, 2008 compared with 2000), as did the complication rate as a result of urinary tract infection/sepsis (odds ratio 1.72, 95% confidence interval 1.41–2.10, 2008 compared with 2000).

Conclusions

There has been an increase in the complication rate after transrectal ultrasound-guided biopsy of the prostate in England between 2000 and 2008, predominantly as a result of infections. Age and comorbid conditions seem to represent the two most important risk factors for occurrence of post-biopsy complications.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.