Prognostic impact of trisomy 21 in follicular lymphoma
Takeki Mitsui
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorAkihiko Yokohama
Division of Blood Transfusion Service, Gunma University Hospital, Maebashi, Japan
Search for more papers by this authorHiromi Koiso
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorHiroaki Shimizu
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorTakuma Ishizaki
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorHiroyuki Irisawa
Division of Haematology, Gunma Prefectural Cancer Centre, Ohta, Japan
Search for more papers by this authorMakiko Takizawa
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorTakayuki Saitoh
Department of Laboratory Sciences, Gunma University Graduate School of Health Science, Maebashi, Japan
Search for more papers by this authorKayoko Murayama
Division of Haematology, Gunma Prefectural Cancer Centre, Ohta, Japan
Search for more papers by this authorMorio Matsumoto
Division of Haematology, National Hospital Organization Shibukawa Medical Centre, Shibukawa, Japan
Search for more papers by this authorHiroshi Handa
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorJunko Hirato
Department of Pathology, Gunma University Hospital, Maebashi, Japan
Search for more papers by this authorMasaru Kojima
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine, Mibu, Japan
Search for more papers by this authorHirokazu Murakami
Department of Laboratory Sciences, Gunma University Graduate School of Health Science, Maebashi, Japan
Search for more papers by this authorCorresponding Author
Norifumi Tsukamoto
Oncology Centre, Gunma University Hospital, Maebashi, Japan
Correspondence: Norifumi Tsukamoto, Oncology Centre, Gunma University Hospital; 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
E-mail: [email protected]
Search for more papers by this authorTakeki Mitsui
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorAkihiko Yokohama
Division of Blood Transfusion Service, Gunma University Hospital, Maebashi, Japan
Search for more papers by this authorHiromi Koiso
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorHiroaki Shimizu
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorTakuma Ishizaki
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorHiroyuki Irisawa
Division of Haematology, Gunma Prefectural Cancer Centre, Ohta, Japan
Search for more papers by this authorMakiko Takizawa
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorTakayuki Saitoh
Department of Laboratory Sciences, Gunma University Graduate School of Health Science, Maebashi, Japan
Search for more papers by this authorKayoko Murayama
Division of Haematology, Gunma Prefectural Cancer Centre, Ohta, Japan
Search for more papers by this authorMorio Matsumoto
Division of Haematology, National Hospital Organization Shibukawa Medical Centre, Shibukawa, Japan
Search for more papers by this authorHiroshi Handa
Department of Haematology, Gunma University Graduate School of Medicine, Maebashi, Japan
Search for more papers by this authorJunko Hirato
Department of Pathology, Gunma University Hospital, Maebashi, Japan
Search for more papers by this authorMasaru Kojima
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine, Mibu, Japan
Search for more papers by this authorHirokazu Murakami
Department of Laboratory Sciences, Gunma University Graduate School of Health Science, Maebashi, Japan
Search for more papers by this authorCorresponding Author
Norifumi Tsukamoto
Oncology Centre, Gunma University Hospital, Maebashi, Japan
Correspondence: Norifumi Tsukamoto, Oncology Centre, Gunma University Hospital; 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
E-mail: [email protected]
Search for more papers by this authorSummary
The chromosomal abnormalities associated with follicular lymphoma (FL) prognosis are not fully elucidated. Here, we evaluated the pattern of chromosomal abnormalities in FL, and clarified the correlations between the cytogenetic features and clinical outcome. Cytogenetic analysis was performed using standard methods of Giemsa-banding at diagnosis for 201 FL patients admitted to our hospitals between 2001 and 2013. The identified chromosomal abnormalities were: t(14;18)(q32;q21) (59·2%), +X (17·9%), del(6)(q)/-6 (16·9%), +7 (14·4%), abnormality of 1q12-21/1q (12·9%), del(13)(q)/-13 (11·9%), abnormality of 3q27 (10·4%), abnormality of 10q22-24 (10·0%), +12/dup(12)(q) (10·0%), abnormality of 1p21-22/1p (9·0%), +18 (9·0%), del(17)(p)/-17 (5·0%), and a complex karyotype (54·7%). Patients with trisomy 21 had a significantly shorter progression-free survival (P = 0·00171) and overall survival (OS) (P < 0·001) than those without trisomy 21; additionally, patients with trisomy 21 in the rituximab-treated cohort also had a significantly shorter OS (P = 0·000428). Multivariate analysis identified trisomy 21 as an independent risk factor in our cohorts with or without t(14;18) (P = 0·015). In conclusion, the presence of trisomy 21 was an independent risk factor for in FL. Chromosomal analysis of FL patients at diagnosis can provide useful information about their expected survival.
Conflict of interest
The authors declare that they have no conflict of interest.
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