Pre-Dialysis Neutrophil-Lymphocyte Ratio, a Novel and Strong Short-Term Predictor of All-Cause Mortality in Patients With Diabetic Nephropathy: Results From a Single-Center Study
Corresponding Author
Hiroyuki Sato
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Address correspondence and reprint requests to Hiroyuki Sato, Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimitishita Hebita, Ishinomaki, Miyagi, 986-8522, Japan. E-mail: [email protected]Search for more papers by this authorYoichi Takeuchi
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorKen Matsuda
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorSaeko Kagaya
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorAyako Saito
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorHirotaka Fukami
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorYoshie Ojima
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorTasuku Nagasawa
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorCorresponding Author
Hiroyuki Sato
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Address correspondence and reprint requests to Hiroyuki Sato, Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimitishita Hebita, Ishinomaki, Miyagi, 986-8522, Japan. E-mail: [email protected]Search for more papers by this authorYoichi Takeuchi
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorKen Matsuda
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorSaeko Kagaya
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorAyako Saito
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorHirotaka Fukami
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorYoshie Ojima
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorTasuku Nagasawa
Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan
Search for more papers by this authorAbstract
Neutrophil-lymphocyte ratio (NLR) is an inflammatory marker affecting the prognosis of end-stage renal disease (ESRD) patients. This study aimed to evaluate NLR levels predicting all-cause mortality in ESRD patients with diabetic nephropathy (DN), which have not been evaluated. We recruited 151 isolated DN patients who started hemodialysis between January 2009 and December 2014 at the Japanese Red Cross Ishinomaki Hospital. The primary outcomes were 1- and 3-year survival rates. The association between NLR and survival rate was evaluated using the Kaplan–Meier method and Cox proportional hazard regression analysis. Patients with an NLR ≥ 3.5 had a significantly higher mortality rate than did those with an NLR < 3.5 (log rank P = 0.02). The area under the curve (AUC) of 1-year survival for NLR was significantly larger than that for other commonly used nutritional and inflammatory variables. NLR was a more accurate predictor than other well-known markers.
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