Adult T-cell leukemia/lymphoma in Jujuy, north-west Argentina
Oscar Marin
Department of Pathology, Pablo Soria Hospital, Argentina,
Search for more papers by this authorKazuhisa Hasui
Second Department of Pathology, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima
Second Department of Anatomy, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima
Search for more papers by this authorCarlos Remondegui
Section of Epidemiology, San Roque Hospital, San Salvador de Jujuy, Argentina,
Search for more papers by this authorEiichi Sato
Second Department of Pathology, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima
Search for more papers by this authorMoe Moe Aye
Division of Molecular Pathology and Genetic Epidemiology, Center of Chronic Viral Diseases, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima and
Search for more papers by this authorNorihiro Takenouchi
Division of Molecular Pathology and Genetic Epidemiology, Center of Chronic Viral Diseases, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima and
Search for more papers by this authorShuji Izumo
Division of Molecular Pathology and Genetic Epidemiology, Center of Chronic Viral Diseases, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima and
Search for more papers by this authorKazuo Tajima
Division of Epidemiology, Research Institute, Aichi Prefectural Cancer Center, Nagoya, Japan
Search for more papers by this authorOscar Marin
Department of Pathology, Pablo Soria Hospital, Argentina,
Search for more papers by this authorKazuhisa Hasui
Second Department of Pathology, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima
Second Department of Anatomy, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima
Search for more papers by this authorCarlos Remondegui
Section of Epidemiology, San Roque Hospital, San Salvador de Jujuy, Argentina,
Search for more papers by this authorEiichi Sato
Second Department of Pathology, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima
Search for more papers by this authorMoe Moe Aye
Division of Molecular Pathology and Genetic Epidemiology, Center of Chronic Viral Diseases, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima and
Search for more papers by this authorNorihiro Takenouchi
Division of Molecular Pathology and Genetic Epidemiology, Center of Chronic Viral Diseases, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima and
Search for more papers by this authorShuji Izumo
Division of Molecular Pathology and Genetic Epidemiology, Center of Chronic Viral Diseases, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima and
Search for more papers by this authorKazuo Tajima
Division of Epidemiology, Research Institute, Aichi Prefectural Cancer Center, Nagoya, Japan
Search for more papers by this authorAbstract
Human T-cell leukemia virus type 1 (HTLV-1) infection is prevalent in native Americans living in the Andes. Some of their malignant lymphomas (ML) show a peculiar histology suggestive of adult T-cell leukemia/lymphoma (ATLL). To determine whether ML resembling ATLL are indeed ATLL, re-analysis of 34 cases occurring in Jujuy, a province of Argentina, was conducted, concentrating on immunological phenotype, integration of HTLV-1 proviral DNA, expression of HTLV-1 p40Tax and p27Rex, and infection of Epstein–Barr virus (EBV). The ML were 22 cases of mature peripheral T-cell and natural killer (NK)-cell neoplasm (mT/NKN), 11 B-cell malignant neoplasms and one Hodgkin's lymphoma. Polymerase chain reaction against the HTLV-1 proviral DNA, using DNA extracted from paraffin sections, indicated integration of the HTLV-1 proviral DNA in three cases of eight mT/NKN. Two other cases of mT/NKN were positive for anti-HTLV-1 antibodies. Expression of p40Tax and p27Rex was detected in all five of these mT/NKN cases associated with HTLV-1. As such, these five mT/NKN were rediagnosed as ATLL. In situ hybridization signals for EBV-encoded small nuclear early region-1 were detected in nine cases of mT/NKN, of which five cases of NK-cell lymphoma were found to have cytoplasmic CD3 expression, a CD56 phenotype and positivity of TIA1. According to the new World Health Organization classification, the mT/NKN class includes five cases of ATLL and five cases of NK-cell lymphomas. The five cases of ATLL were of native American extraction from an HTLV-1-endemic area around Jujuy, north-west Argentina.
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