Functional connectivity between the habenula and default mode network and its association with the antidepressant effect of ketamine
Mingqia Wang
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorXiaoyu Chen
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorYiru Hu
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorYangling Zhou
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, Guangdong, China
Search for more papers by this authorChengyu Wang
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorWei Zheng
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorWeijian Liu
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorXiaofeng Lan
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorCorresponding Author
Yuping Ning
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, Guangdong, China
The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China
Correspondence Yuping Ning and Bin Zhang, The Affiliated Brain Hospital of Guangzhou Medical University, Mingxin Rd 36, Liwan District, Guangzhou 510370, Guangdong, China.
Email: [email protected] and
Search for more papers by this authorCorresponding Author
Bin Zhang
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, Guangdong, China
Correspondence Yuping Ning and Bin Zhang, The Affiliated Brain Hospital of Guangzhou Medical University, Mingxin Rd 36, Liwan District, Guangzhou 510370, Guangdong, China.
Email: [email protected] and
Search for more papers by this authorMingqia Wang
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorXiaoyu Chen
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorYiru Hu
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorYangling Zhou
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, Guangdong, China
Search for more papers by this authorChengyu Wang
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorWei Zheng
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorWeijian Liu
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorXiaofeng Lan
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Search for more papers by this authorCorresponding Author
Yuping Ning
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, Guangdong, China
The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China
Correspondence Yuping Ning and Bin Zhang, The Affiliated Brain Hospital of Guangzhou Medical University, Mingxin Rd 36, Liwan District, Guangzhou 510370, Guangdong, China.
Email: [email protected] and
Search for more papers by this authorCorresponding Author
Bin Zhang
PsyNI Lab, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, Guangdong, China
Correspondence Yuping Ning and Bin Zhang, The Affiliated Brain Hospital of Guangzhou Medical University, Mingxin Rd 36, Liwan District, Guangzhou 510370, Guangdong, China.
Email: [email protected] and
Search for more papers by this authorAbstract
Background
Recently, an animal model for depression has shown that ketamine, an N-methyl- d-aspartate receptor (NMDAR) antagonist, elicits a rapid-acting antidepressant effect by blocking NMDAR-dependent bursting in the lateral habenula (Hb). However, evidence from human studies remains scarce.
Methods
This study explored the changes of resting-state functional connectivity (FC) of the Hb in responders and nonresponders who was diagnosed with unipolar or bipolar depression before and after ketamine treatment. The response was defined as a ≥50% reduction in the total MADRS score at Day 13 (24 h following the sixth infusion) in comparison with the baseline score. Correlation analyses were performed to identify an association between symptom improvement and the signals of the significantly different brain regions detected in the above imaging analysis.
Results
In the post-hoc region-of-interest analysis, an enhanced baseline FC between Hb and several hubs of the default mode network (including angulate cortex, precuneus, medial prefrontal cortex, and middle temporal cortex) was observed in responders (≥50% decrease in the Montgomery–Asberg Scale at 2 weeks) compared with nonresponders.
Conclusions
These pilot findings may suggest a potential neural mechanism by which ketamine exerts its robust antidepressant efficacy via downregulation of aberrant habenular FC with parts of the default mode network.
CONFLICT OF INTERESTS
The authors declare that there are no conflict of interests.
Open Research
DATA AVAILABILITY STATEMENT
Some or all data used during the study are available from the corresponding author by request.
Supporting Information
| Filename | Description |
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| da23238-sup-0001-2021_1113_Re1_SupplementaryMaterial_Table_S1_S2.docx19.7 KB | Supplementary information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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