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Fascinating Hydrogen Atom Transfer Chemistry of Alkenes Inspired by Problems in Total Synthesis^†

Dr. Antoine Simonneau

Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin (Germany) http://www.organometallics.tu-berlin.de

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Prof. Dr. Martin Oestreich,

Corresponding Author

Prof. Dr. Martin Oestreich

[email protected]

Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin (Germany) http://www.organometallics.tu-berlin.de

Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin (Germany) http://www.organometallics.tu-berlin.de Search for more papers by this author

Dr. Antoine Simonneau,

Dr. Antoine Simonneau

Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin (Germany) http://www.organometallics.tu-berlin.de

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Prof. Dr. Martin Oestreich,

Corresponding Author

Prof. Dr. Martin Oestreich

[email protected]

Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin (Germany) http://www.organometallics.tu-berlin.de

Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin (Germany) http://www.organometallics.tu-berlin.de Search for more papers by this author

First published: 20 February 2015

https://doi.org/10.1002/anie.201500557

Citations: 30

^†

A.S. gratefully acknowledges the Alexander von Humboldt Foundation for a postdoctoral fellowship (2014–2015). M.O. is indebted to the Einstein Foundation (Berlin) for an endowed professorship.

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Graphical Abstract

The magical HAT: Radical hydrofunctionalization processes of alkenes recently witnessed tremendous progress. The coupling of heteroatom-substituted alkenes was achieved by means of catalytic hydrogen atom transfer (HAT), enabling the construction of functionalized quaternary centers with unusual ease. Challenging thermodynamically controlled hydrogenations and isomerizations of alkenes as well as reductions of vinyl halides were accomplished using HAT processes.

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March 16, 2015

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Fascinating Hydrogen Atom Transfer Chemistry of Alkenes Inspired by Problems in Total Synthesis^†

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Fascinating Hydrogen Atom Transfer Chemistry of Alkenes Inspired by Problems in Total Synthesis^†