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Enamine/Enolate-Mediated Organocatalytic Azide–Carbonyl [3+2] Cycloaddition Reactions for the Synthesis of Densely Functionalized 1,2,3-Triazoles†
Prof. Dr. Sripada S. V. Ramasastry,
Corresponding Author
Prof. Dr. Sripada S. V. Ramasastry
Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, S. A. S. Nagar, Manuali PO, Punjab 140306 (India)
Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, S. A. S. Nagar, Manuali PO, Punjab 140306 (India)Search for more papers by this authorProf. Dr. Sripada S. V. Ramasastry,
Corresponding Author
Prof. Dr. Sripada S. V. Ramasastry
Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, S. A. S. Nagar, Manuali PO, Punjab 140306 (India)
Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, S. A. S. Nagar, Manuali PO, Punjab 140306 (India)Search for more papers by this author†
Financial support from IISER Mohali and the Department of Science and Technology (DST), Govt. of India is gratefully acknowledged.
Graphical Abstract
Organocatalytic click! Recent advances in the metal-free enamine/enolate-mediated azide–carbonyl [3+2] cycloaddition reaction are discussed. These approaches require neither a metal catalyst nor alkyne substrates. Owing to the ready availability of carbonyl compounds, these methods thus offer excellent alternatives for the synthesis of 1,4-/1,5-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles.
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