Kidney transplantation requires significant immunosuppression to maximize graft outcomes and reduce the risk of rejection. Infection post-transplantation can be either routine infections, as experienced by no immunosuppressed patients, or true opportunistic infections, mostly experienced by immunocompromised patients. The lack of a valid standard approach for defining sepsis makes it difficult to determine the true incidence of community-acquired infection and sepsis. Hospital-acquired infection is present at hospital admission or within 48 hours after admission in patients. Most studies reporting opportunistic infection lack a formal definition of this term and when present, heterogeneity between studies was noted with regard to the types of infections considered or reported as opportunistic. Influenza is usually a community-acquired infection. Donor-derived infections are important as they might give more severe and serious complications in recipients. This chapter presents a summary of resistance rates that are reported in the literature for common gram negative bacteria.