H215O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans
Frank Q. Ye
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorKaren Faith Berman
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorTimothy Ellmore
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorGiuseppe Esposito
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorJohn D. van Horn
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorYihong Yang
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorJeff Duyn
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorAnne M. Smith
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorJoseph A. Frank
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorDaniel R. Weinberger
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorCorresponding Author
Alan C. McLaughlin
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Building 10, Room B1D-69, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892===Search for more papers by this authorFrank Q. Ye
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorKaren Faith Berman
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorTimothy Ellmore
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorGiuseppe Esposito
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorJohn D. van Horn
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorYihong Yang
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorJeff Duyn
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorAnne M. Smith
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorJoseph A. Frank
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorDaniel R. Weinberger
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Search for more papers by this authorCorresponding Author
Alan C. McLaughlin
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Building 10, Room B1D-69, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892===Search for more papers by this authorAbstract
Steady-state arterial spin tagging approaches can provide quantitative images of CBF, but have not been validated in humans. The work presented here compared CBF values measured using steady-state arterial spin tagging with CBF values measured in the same group of human subjects using the H215O IV bolus PET method. Blood flow values determined by H215O PET were corrected for the known effects of incomplete extraction of water across the blood brain barrier. For a cortical strip ROI, blood flow values determined using arterial spin tagging (64 ± 12 cc/100g/min) were not statistically different from corrected blood flow values determined using H215O PET (67 ± 13 cc/100g/min). However, for a central white matter ROI, blood flow values determined using arterial spin tagging were significantly underestimated compared to corrected blood flow values determined using H215O PET. This underestimation could be caused by an underestimation of the arterial transit time for white matter regions. Magn Reson Med 44:450–456, 2000. Published 2000 Wiley-Liss, Inc.
REFERENCES
- 1 Detre JA, Leigh JS, Williams DS, Koretsky A. Perfusion imaging. Magn Reson Med 1992; 23: 37–45.
- 2 Williams DS, Detre JA, Leigh JS, Koretsky AP. Magnetic resonance imaging of perfusion using spin inversion of arterial water. Proc Nat Acad Sci USA 1992; 89: 212–216.
- 3 Roberts DA, Detre JA, Bolinger L, Insko, EK, Leigh JS. Quantitative magnetic resonance imaging of human brain perfusion at 1.5 T using steady-state inversion of arterial water. Proc Nat Acad Sci USA 1994; 91: 33–37.
- 4 Ye FQ, Pekar JJ, Jezzard P, Duyn J, Frank JA, McLaughlin AC. Perfusion imaging of the human brain at 1.5 T using a single-shot EPI spin tagging approach. Magn Reson Med 1996; 36: 219–224.
- 5 Alsop DC, Detre JA. Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab 1996; 16: 1236–1249.
- 6 Ye FQ, Mattay VS, Jezzard P, Frank JA, Weinberger DR, McLaughlin AC. Correction for vascular artifacts in cerebral blood flow values measured using arterial spin tagging techniques. Magn Reson Med 1997; 37: 226–235.
- 7 Ye FQ, Smith AM, Yang Y, Duyn J, Mattay VS, Ruttimann EU, Frank JA, Weinberger DR, McLaughlin AC. Quantitation of regional cerebral blood flow increases during motor activation: A steady-state arterial spin tagging study. Neuroimage 1997; 6: 104–112.
- 8
Ye FQ,
Yang Y,
Duyn J,
Mattay VS,
Frank JA,
Weinberger DR,
McLaughlin AC.
Quantitation of regional cerebral blood flow increases during motor activation: a multislice, steady-state, arterial spin tagging study.
Magn Reson Med
1999;
42: 404–407.
10.1002/(SICI)1522-2594(199908)42:2<404::AID-MRM23>3.0.CO;2-0 CAS PubMed Web of Science® Google Scholar
- 9 Ye FQ, Smith AM, Mattay VS, Ruttimann UE, Frank JA, Weinberger DR, McLaughlin AC. Quantitation of regional cerebral blood flow increases in prefrontal cortex during a working memory task: a steady-state arterial spin tagging study. Neuroimage 1998; 8: 44–49.
- 10 Detre JA, Alsop DC, Vives LR, Maccotta L, Teener JW, Raps EC. Noninvasive MRI evaluation of cerebral blood flow in cerebrovascular disease. Neurology 1998; 50: 633–641.
- 11 Pekar J, Jezzard P, Roberts DA, Leigh JS, Frank JA, McLaughlin AC. Perfusion imaging with compensation for asymmetric magnetization transfer effects. Magn Reson Med 1996; 35: 70–79.
- 12 Zhang W, Williams DS, Detre JA, Koretsky AP. Measurement of brain perfusion by volume-localized NMR spectroscopy using inversion of arterial water spins: accounting for transit time and cross-relaxation. Magn Reson Med 1992; 25: 362–371.
- 13 Walsh EG, Minematsu K, Leppo J, Moore SC. Radioactive microsphere validation of a volume localized continuous saturation perfusion measurement. Magn Reson Med 1994; 31: 147–153.
- 14 Yang Y, Glover GH, van Gelderen P, Mattay VS, Santha AKS, Sexton R, Ramsey NF, Moonen CTW, Weinberger DR, Frank JA, Duyn J. Fast 3D functional magnetic resonance imaging at 1.5 T with spiral acquisition. Magn Reson Med 1996; 36: 620–626.
- 15 Herscovitch P, Raichle ME. What is the correct value for the brain-blood partition coefficient for water? J Cereb Blood Flow Metab 1985; 5: 65–69.
- 16 Daube-Witherspoon ME, Chon KS, Green SL, Carson RE, Herscovitch P. Factors affecting dispersion correction for continuous blood withdrawal and counting systems. J Nucl Med 1992; 33: 1010.
- 17 Iida H, Kanno I, Miura S, Murakami M, Takahashi K, Uemura K. Evaluation of regional differences of tracer appearance time in cerebral tissues using [15O] water and dynamic positron emission tomography. J Cereb Blood Flow Metab 1988; 8: 285–288.
- 18 Koeppe RA, Holden JE, Ip WR. Performance comparison of parameter estimation techniques for the quantitation of local cerebral blood flow by dynamic positron computed tomography. J Cereb Blood Flow Metab 1985; 5: 224–234.
- 19 Woods RP, Grafton ST, Holmes CJ, Cherry SR, Mazziotta JC. Automated image registration: I. General methods and intrasubject, intramodality validation. J Comput Assist Tomogr 1998; 22: 141–154.
- 20
Eichling JO,
Raichle ME,
Grubb RL,
Ter-Pogossian MM.
Evidence of the limitations of water as a freely diffusible tracer in brain of the Rhesus monkey.
Circ Res
1994;
35: 358–364.
10.1161/01.RES.35.3.358 Google Scholar
- 21 Raichle ME, Martin WRW, Herscovitch P, Mintun MA, Markham J. Brain blood flow measured with intravenous H215O. II. Implementation and validation. J Nucl Med 1983; 24: 790–798.
- 22 Herscovitch P, Raichle ME, Kilbourn MR, Welch MJ. Positron emission tomographic measurement of cerebral blood flow and permeability-surface area product of water using [15O] water and [11C] butanol. J Cereb Blood Flow Metab 1987; 7: 527–542.
- 23 Berridge MS, Adler LP, Nelson AD, Cassidy EH, Muzic RF, Bednarczyk EM, Miraldi F. Measurement of human cerebral blood flow with [15O]butanol and positron emission tomography. J Cereb Blood Flow Metab 1991; 11: 707–715.
- 24 Silva AC, Zhang W, Williams DS, Koretsky AP. Estimation of water extraction fractions in rat brain using magnetic resonance measurement of perfusion with arterial spin labeling. Magn Reson Med 1997; 37: 58–68.
- 25 Pawlik G, Rackl A, Bing RJ. Quantitative capillary topography and blood flow in the cerebral cortex of cats: an in vivo microscopic study. Brain Res 1981; 208: 35–58.
- 26 Kennan RP, Gao J-H, Zhong J, Gore JC. A general model of microcirculatory blood flow effects in gradient sensitized MRI. Med Phys 1994; 21: 539–545.
- 27 St. Lawrence KS, Frank JA, McLaughlin AC. Effect of restricted water exchange rate on cerebral blood flow values calculated with arterial spin tagging: a theoretical investigation. Magn Reson Med 2000; 44: 440–449.
- 28 Ye FQ, Mattay VS, Frank JA, Weinberger DR, McLaughlin AC. Comparison of white and grey matter transit times in spin tagging experiments. In: Proceedings of the 7th Annual Meeting of ISMRM, Philadelphia, 1999. p 1857.
- 29 Frackowiak RSJ, Lenzi G-L, Jones T, Heather JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr 1980; 4: 727–736.
- 30 Lammertsma AA, Frackowiak RSJ, Hoffman JM, Huang S-C, Weinberg IN, Dahlbom M, MacDonald NS, Hoffman EJ, Mazziotta JC, Heather JD, Forse GR, Phelps ME, Jones T. The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water. J Cereb Blood Flow Metab 1989; 9: 461–470.
- 31 Herscovitch P, Markham J, Raichle ME. Brain blood flow measured with intravenous H215O. 1. Theory and error analysis. J Nucl Med 1983; 24: 782–789.
- 32 Koeppe RA, Hutchins GD, Rothley JM, Hichwa RD. Examination of assumptions for local cerebral blood flow studies in PET. J Nucl Med 1987; 28: 1695–1703.
- 33 Lammerstma AA, Jones T, Frackowiak RSJ, Lenzi G-L. A theoretical study of the steady-state model for measuring regional cerebral blood flow and oxygen utilization using oxygen-15. J Comput Assist Tomogr 1981; 5: 544–550.
- 34 Jones SC, Greenberg JH, Reivich M. Error analysis for the determination of cerebral blood flow with the continuous inhalation of 15O-labeled carbon dioxide and positron emission tomography. J Comput Assist Tomogr 1982; 6: 116–124.
