Auxiliary heterotopic liver transplantation in the rat: A simplified model using cuff technique and application for congenitally hyperbilirubimemic Gunn rat
Corresponding Author
Eiji Kobayashi M.D., Ph.D.
Department of Surgery, Meikai University, Sakado, Saitama, Japan
Department of Clinical Pharmacology, Jichi Medical School, Kawachi, Tochigi, Japan
Department of Surgery, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Department of Clinical Pharmacology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi, 329-04, JapanSearch for more papers by this authorYoko Yoshida M.D.
Department of Gastroenterology, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Search for more papers by this authorMasumi Nozawa M.D., Ph.D.
Department of Surgery, Meikai University, Sakado, Saitama, Japan
Search for more papers by this authorShuuji Hishikawa M.D.
Department of Surgery, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Search for more papers by this authorTakeo Yamanaka M.D., Ph.D.
Department of Gastroenterology, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Search for more papers by this authorMichio Miyata M.D., Ph.D.
Department of Surgery, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Search for more papers by this authorAkio Fujimura M.D., Ph.D.
Department of Clinical Pharmacology, Jichi Medical School, Kawachi, Tochigi, Japan
Search for more papers by this authorCorresponding Author
Eiji Kobayashi M.D., Ph.D.
Department of Surgery, Meikai University, Sakado, Saitama, Japan
Department of Clinical Pharmacology, Jichi Medical School, Kawachi, Tochigi, Japan
Department of Surgery, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Department of Clinical Pharmacology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi, 329-04, JapanSearch for more papers by this authorYoko Yoshida M.D.
Department of Gastroenterology, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Search for more papers by this authorMasumi Nozawa M.D., Ph.D.
Department of Surgery, Meikai University, Sakado, Saitama, Japan
Search for more papers by this authorShuuji Hishikawa M.D.
Department of Surgery, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Search for more papers by this authorTakeo Yamanaka M.D., Ph.D.
Department of Gastroenterology, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Search for more papers by this authorMichio Miyata M.D., Ph.D.
Department of Surgery, Omiya Medical Center, Jichi Medical School, Amanuma, Omiya, Saitama, Japan
Search for more papers by this authorAkio Fujimura M.D., Ph.D.
Department of Clinical Pharmacology, Jichi Medical School, Kawachi, Tochigi, Japan
Search for more papers by this authorAbstract
To study the immunological and metabolic effects of auxiliary liver transplantation (ALT), a simple ALT model in rats was developed using the cuff application. Effects of transient parking of normal liver were tested in congenitally hyperbilirubinemic Gunn rats. Serum bilirubin concentrations in Gunn rats, transplanted heterotopically with normal livers of Wistar rats, were dramatically reduced and maintained within normal levels. The graftectomy was performed safely 1 month after transplantation, but total bilirubin levels did not return to the preoperative value of the Gunn rats. It is possible that hepatic stem cells included in ALT liver migrated to the host liver and differentiated into cells capable of producing certain enzymes. © 1998 Wiley-Liss, Inc. MICROSURGERY 18:97-102 1998
References
- 1 Terpstra OT, Reuvers CB, Schalm SW: Auxilialy heterotopic liver transplantation. Transplantation 45: 1003–1007, 1988.
- 2 Metselaar HJ, Hesselink EJ, de Rave S, et al: Recovery of failing liver after auxiliary heterotopic transplantation. Lancet 335: 1156–1157, 1990.
- 3 Stampfl DA, Munoz J, Moritz MJ, et al: Heterotopic liver transplantation for fulminant Wilson's disease. Gastroenterology 99: 1834–1836, 1990.
- 4 Gubernatis G, Pichlmayr R, Kemnitz J, et al: Auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure: First successful case report. World J Surg 15: 660–666, 1991.
- 5 Bismuth H, Azoulay D, Samuel D, et al: Auxiliary ratial orthotopic liver transplantation for fulminant hepatitis. Ann Surg 224: 712–726, 1996.
- 6 Boudjema K, Jaeck D, Simeoni U, et al: Temporary auxiliary liver transplantation for subacute liver failure in a child. Lancet 342: 778–779, 1993.
- 7 Broelsch CE, Emond JC, Whitington PF, et al: Application of reducedsize liver transplantation as split grafts, auxiliary orthotopic grafts and living related segmental transplants. Ann Surg 212: 368–375, 1990.
- 8 Whitingyon PF, Emond JC, Heffron T, et al: Orthotopic auxiliary liver transplantation for Crigler—Najjar syndrome type 1 Lancet 342: 779–780, 1993.
- 9 Terpstra OT: Auxiliary liver grafting: A new concept in liver transplantation. Lancet 342: 758, 1993.
- 10 Kobayashi E, Nozawa M, Miyata M: Auiliary heterotopic liver transplantation in the rat. Proc Second Cong Int Soc Exp Microsurg 2: 199–205, 1994.
- 11 Gunn CK: Hereditary acholuric jaundice in a new mutant strain of rat. J Hered 29: 137–139, 1939.
- 12 Kobayashi E, Kamada N, Goto S, Miyata M: Protocol for the technique of orthotopic liver transplantation in the rat. Microsurgery 14: 541–546, 1993.
- 13 Müller G: A simple technique for heterotopic auxiliary liver transplantation in the rat. Transplantation 36: 221–223, 1983.
- 14 Kobayashi E, Favila-Castillo L, Kamada N. Antibody formation in the transplanted spleen in the rat: A simple method of splenic transplantation in the rat using the cuff technique. Microsurgery 17: 221–225, 1997.
- 15 Lee S, Edgington TS: Heterotopic liver transplantation using inbred rat strains. Am J Pathol 52: 649, 1966.
- 16 Hess F, Jerusalem C, van der Heyde NM: Advantage of auxiliary liver homotransplantation in rats. Arch Surg 104: 76, 1972.
- 17 Marino A, Ferrero ME. Heterotopic liver grafting in the rat. Transplantation 39: 329–331, 1985.
- 18 Hoeden B, Jablonskj P, Grossman H, et al: The importance of the hepatic artery in rat liver transplantation. Transplantation 47: 428–431, 1989.
- 19 Kamada N, Sumimoto R, Kaneda K: The value of hepatic artery reconstruction as a technique in rat liver transplantation. Surgery 111: 195–200, 1992.
- 20 Daloze P, Delvin EE, Glorieux FH, et al: Replacement therapy for inherited enzyme deficiency: Liver orthotopic transplantation in Niemann–Pick disease type A. Am J Med Genet 1: 229–239, 1977.
- 21 Carlson DE, Busuttil RW, Giudici TA, Barranger JA: Orthotopic liver transplantation in the treatment of complications of type 1 Gaucher disease. Transplantation 49: 1192, 1990.
- 22 DuCerf C, Bancel B, Caillon P, et al: Orthotopic liver transplantation for type 1 Gaucher's disease. Transplantation 53: 1141–1143, 1992.
- 23 Starl TE, Demetris AJ, Trucco M, et al: Chimerism after liver transplantation for type IV glycogen storage disease and type 1 Gaucher's disease. New Engl J Med 328: 745–749, 1993.
- 24 Starzl TE, Bilheimer DW, Bahnson HT, et al: Heart–liver transplantation in a patient with familial hypercholesterolaemia. Lancet 1: 1382–1383, 1984.
- 25 Bilheimer DW, Goldstein JL, Grundy SM, et al: Liver transplantation provides low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. New Engl J Med 311: 1658–1664, 1984.
- 26 Starzl TE, Demetris AJ, Murase N, et al: Cell migration, chimerism and graft acceptance. Lancet 339: 1579–1582, 1993.
- 27 Watanabe H, Miyaji C, Seki S, et al. c-kit+ stem cells and thymocyte precursors in the liver of adult mice. J Exp Med 184: 687–693, 1996.
- 28 Taniguchi H, Toyoshima T, Fukao K, et al: Presence of hematopoietic stem cells in the adult liver. Nature Med 2: 198–203, 1996.
- 29 Kobayashi E, Kamada N, Delriviere L, et al: Migration of donor cells into the thymus is not essential for induction and maintenance of systemic tolerance after liver transplantation in the rat. Immunology 84: 333–336, 1995.
- 30 Arai Y, Kobayashi E, Nozawa M, et al: Characteristic changes of hepatic lymphocytes after ischemia-reperfusion. Transplantation 61: 848–849, 1996.
- 31 Goto S, Kamada N, Lord R, et al: Induction of natural chimerism after retransplantation of the liver in rats. Transplantation 58: 1230–1235, 1994.
- 32 Schmid R, Axelrod J, Hammaker L, et al: Congenital jaundice in the rat, due to a defect in glucuronide formation. J Clin Invest 37: 1123–1130, 1958.
- 33 Nozawa M, Otsu H, Ikebukuro H, et al: Effects of fetal liver transplantation in rats with congenital metabolic disease. Transplant Proc 23: 889–891, 1991.
- 34
Okazaki T,
Nozawa M,
Otsu I,
Makino S:
Effects of orthotopic liver and fetal liver transplantation in hereditary hyperbilirubinemic Gunn rat.
Juntendo Med J (Jpn)
39:
96–103,
1993.
10.14789/pjmj.39.96 Google Scholar
- 35 Arai Y, Kobayashi E, Nozawa M, et al: Hepatic lymphomyeloid cell (HLC) transplantation for hyperbilirubinemic Gunn rats: The characters of HLCs in vivo and in vitro. Int Hepatic Comm 3: s–139, 1996.
Citing Literature
