Original Research-Clinical Science
Negative-pressure wound therapy for III/IV pressure injuries: A meta-analysis
Yi-Ping Song MSc,
Lei Wang MSc,
Bao-Fang Yuan BD,
Hong-Wu Shen BD,
Lin Du MSc,
Ji-Yu Cai MSc,
Hong-Lin Chen MSc,
Yi-Ping Song MSc
School of Medicine, Nantong University, Nantong, Jiangsu, P.R. China
Search for more papers by this authorLei Wang MSc
Information Department, The Third People's Hospital of Nantong, Nantong, Jiangsu, P.R. China
Search for more papers by this authorBao-Fang Yuan BD
Nursing Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P. R. China
Search for more papers by this authorHong-Wu Shen BD
Nursing Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P. R. China
Search for more papers by this authorLin Du MSc
School of Medicine, Nantong University, Nantong, Jiangsu, P.R. China
Search for more papers by this authorJi-Yu Cai MSc
School of Medicine, Nantong University, Nantong, Jiangsu, P.R. China
Search for more papers by this authorCorresponding Author
Hong-Lin Chen MSc
School of Public Health, Nantong University, Nantong, Jiangsu, P.R. China
Correspondence
Hong-Lin Chen, School of Public Health, Nantong University, Nantong, Jiangsu, P.R. China.
Email: [email protected]
Search for more papers by this authorYi-Ping Song MSc,
Lei Wang MSc,
Bao-Fang Yuan BD,
Hong-Wu Shen BD,
Lin Du MSc,
Ji-Yu Cai MSc,
Hong-Lin Chen MSc,
Yi-Ping Song MSc
School of Medicine, Nantong University, Nantong, Jiangsu, P.R. China
Search for more papers by this authorLei Wang MSc
Information Department, The Third People's Hospital of Nantong, Nantong, Jiangsu, P.R. China
Search for more papers by this authorBao-Fang Yuan BD
Nursing Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P. R. China
Search for more papers by this authorHong-Wu Shen BD
Nursing Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P. R. China
Search for more papers by this authorLin Du MSc
School of Medicine, Nantong University, Nantong, Jiangsu, P.R. China
Search for more papers by this authorJi-Yu Cai MSc
School of Medicine, Nantong University, Nantong, Jiangsu, P.R. China
Search for more papers by this authorCorresponding Author
Hong-Lin Chen MSc
School of Public Health, Nantong University, Nantong, Jiangsu, P.R. China
Correspondence
Hong-Lin Chen, School of Public Health, Nantong University, Nantong, Jiangsu, P.R. China.
Email: [email protected]
Search for more papers by this authorFunding information: Social and People's Livelihood Technology in Nantong city-General Project, Grant/Award Number: MS12019038
Abstract
This meta-analysis was conducted to identify the potential benefits and the efficacy of negative-pressure wound therapy (NPWT) for III/IV pressure injuries (PIs) compared with standard wound care (SWC). Sixteen RCTs with 629 patients were included in our analysis. The methodological quality was assessed by the Cochrane Collaboration Tool. The outcomes included complete ulcer healing rate, wound healing time, pain score, the frequency of dressing change, hospitalization cost, the condition of the exudate, and the wound improvement. The percentage of healing rate was 61.45% for the NPWT group and 36.90% for SWC (95% CI: 1.32-1.70). There were significant differences in wound healing time (WMD = −16.47 days, 95% [CI (−22.36, − 10.59) days, P ≤ .001]). The pain score and hospitalization cost in NPWT was lower compared with SWC group (WMD = −2.39, 95% CI [−3.47, −1.30], P ≤ .001); (SMD = −2.55, 95% CI [−4.07, −1.03], P < .01). The frequency of dressing change in both NPWT groups was greatly reduced (SMD = −3.61, 95% [CI (−4.57, − 2.66) times, P ≤ .001]). Our meta-analysis indicated that NPWT was associated with greater improvements in improving PIs and shorting healing time for III/IV PIs. However, this conclusion needs to be confirmed by high-quality multicenter RCTs.
CONFLICT OF INTEREST
The authors declare that there was no conflict of interest.
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