Volume 55, Issue 12 pp. 2778-2782
CLINICAL RESEARCH FOCUS

How do I interpret a p value?

Sheila F. O'Brien

Corresponding Author

Sheila F. O'Brien

Canadian Blood Services, Ottawa, Ontario, Canada

Address reprint requests to: Sheila F. O'Brien, Epidemiology and Surveillance, Canadian Blood Services, 1800 Alta Vista Drive, Ottawa, ON, Canada K1G 4J5; e-mail: sheila.o'[email protected].Search for more papers by this author
Lori Osmond

Lori Osmond

Canadian Blood Services, Ottawa, Ontario, Canada

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Qi-Long Yi

Qi-Long Yi

Canadian Blood Services, Ottawa, Ontario, Canada

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First published: 06 November 2015
Citations: 9

Supported by Canadian Blood Services.

Abstract

A p-value is a number between 0 and 1 that is extremely useful in interpreting research results. Using comparison of the means of two samples as an example, a p-value <0.05 suggests that there is enough evidence to presume a real difference between groups from which the samples were drawn (that the “null hypothesis” can be rejected). We say that the difference between the means is statistically significant. However, it isn't iron clad proof and there is still a chance that there is really no difference. Furthermore, a statistically significant difference may not be clinically significant if it is not enough to appreciably affect patient outcomes. We describe the theory behind p-values and some common errors in interpretation.

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