A preliminary investigation of sleep quality and patient-reported outcomes in pediatric solid organ transplant candidates
Corresponding Author
Ana M. Gutierrez-Colina
Department of Psychology, University of Georgia, Athens, Georgia
Correspondence
Ana M. Gutierrez-Colina, Cincinnati Children’s Hospital, Medical Center Cincinnati, OH.
Email: [email protected]
Search for more papers by this authorGrace K. Cushman
Department of Psychology, University of Georgia, Athens, Georgia
Search for more papers by this authorCyd K. Eaton
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorLauren F. Quast
Department of Psychology, University of Georgia, Athens, Georgia
Search for more papers by this authorJennifer Lee
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorKristin Loiselle Rich
Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio
Search for more papers by this authorBonney Reed-Knight
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorLaura Mee
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorRene Romero
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorChad Y. Mao
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorRoshan George
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorRonald L. Blount
Department of Psychology, University of Georgia, Athens, Georgia
Search for more papers by this authorCorresponding Author
Ana M. Gutierrez-Colina
Department of Psychology, University of Georgia, Athens, Georgia
Correspondence
Ana M. Gutierrez-Colina, Cincinnati Children’s Hospital, Medical Center Cincinnati, OH.
Email: [email protected]
Search for more papers by this authorGrace K. Cushman
Department of Psychology, University of Georgia, Athens, Georgia
Search for more papers by this authorCyd K. Eaton
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorLauren F. Quast
Department of Psychology, University of Georgia, Athens, Georgia
Search for more papers by this authorJennifer Lee
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorKristin Loiselle Rich
Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio
Search for more papers by this authorBonney Reed-Knight
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorLaura Mee
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorRene Romero
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorChad Y. Mao
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorRoshan George
Children’s Healthcare of Atlanta, Atlanta, Georgia
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
Search for more papers by this authorRonald L. Blount
Department of Psychology, University of Georgia, Athens, Georgia
Search for more papers by this authorAbstract
The current cross-sectional, single-center study aimed to examine sleep quality in a sample of adolescents awaiting solid organ transplantation and to explore associations between sleep quality and both health-related quality of life and barriers to adherence. Thirty adolescents between the ages of 12 and 18 years (M age = 15.26, SD = 1.89) who were awaiting transplantation participated in this study. Participants completed measures of sleep quality, health-related quality of life, and barriers to adherence. T test and correlational analyses were performed to examine study aims. Adolescents awaiting transplantation had significantly lower levels of overall sleep quality compared to published norms of healthy peers. Domains of sleep quality were positively related to emotional and psychosocial health-related quality of life. Sleep quality domains were also negatively related to adherence barriers. This study provides preliminary evidence demonstrating that sleep quality among transplant candidates is compromised, and that poor sleep quality is related to adolescents’ functioning across a number of domains during the pretransplant period. Results highlight the clinical importance of assessing and targeting sleep functioning in adolescents awaiting transplantation in order to reduce the negative influence of suboptimal sleep on functioning during this vulnerable period.
REFERENCES
- 1Anthony SJ, BarZiv SP, Ng VL. Quality of life after pediatric solid organ transplantation. Pediatr Clin North Am. 2010; 57: 559-574.
- 2Anthony SJ, Annunziato RA, Fairey E, Kelly VL, So S, Wray J. Waiting for transplant: physical, psychosocial, and nutritional status considerations for pediatric candidates and implications for care. Pediatr Transplant. 2014; 18: 423-434.
- 3 Organ Procurement and Transplantation Network Bylaws. 2014. Available at http://optn.transplant.hrsa.gov/data/.
- 4Annunziato RA, Fisher MK, Jerson B, Bochkanova A, Shaw RJ. Psychosocial assessment prior to pediatric transplantation: a review and summary of key considerations. Pediatr Transplant. 2010; 14: 565-574.
- 5Eaton C, Gutierrez-Colina AM, Fredericks E, et al. Organ transplantation. In: MC Roberts, R Steele, eds. Handbook of Pediatric Psychology, 5th ed. New York, NY: Guilford Press; 2017.
- 6 National Sleep Foundation. 2006 Sleep in America Poll. Washington, DC: National Sleep Foundation; 2006.
- 7Mindell JA, Owens JA. A clinical guide to pediatric sleep: diagnosis and management of sleep problems. Hagerstown, MD: Lippincott Williams & Wilkins; 2015.
- 8Boergers J, Koinis-Mitchell D. Sleep and culture in children with medical conditions. J Pediatr Psychol. 2010; 35: 915-926.
- 9Davis ID, Baron J, O’Riordan MA, Rosen CL. Sleep disturbances in pediatric dialysis patients. Pediatr Nephrol. 2005; 20: 69-75.
- 10Alfano CA, Gamble AL. The role of sleep in childhood psychiatric disorders. Child Youth Care Forum. 2009; 38(6): 327-340.
- 11Simola P, Liukkonen K, Pitkäranta A, Pirinen T, Aronen ET. Psychosocial and somatic outcomes of sleep problems in children: A 4-year follow-up study. Child Care Health Dev. 2014; 40: 60-67.
- 12Delahaye J, Kovacs E, Sikora D, et al. The relationship between health-related quality of life and sleep problems in children with autism spectrum disorders. Res Autism Spectr Disord. 2014; 8: 292-303.
- 13Fredericks EM, Dore-Stites D, Calderon SY, et al. Relationship between sleep problems and health-related quality of life among pediatric liver transplant recipients. Liver Transpl. 2012; 18: 707-715.
- 14Turner SL, Queen TL, Butner JE, Wiebe DJ, Berg CA. Variations in daily sleep quality and type 1 diabetes management in late adolescents. J Pediatr Psychol. 2016; 41: 661-669.
- 15Bullington P, Pawola L, Walker R, Valenta A, Briars L, John E. Identification of medication non-adherence factors in adolescent transplant patients: The patient's viewpoint. Pediatr Transplant. 2007; 11: 914-921. https://doi.org/10.1111/j.1399-3046.2007.00765.x
- 16Murray CB, Murphy LK, Palermo TM, Clarke GM. Pain and sleep–wake disturbances in adolescents with depressive disorders. J Clin Child Adolesc Psychol. 2012; 41(4): 482-490. https://doi.org/10.1080/15374416.2012.658613
- 17LeBourgeois MK, Giannotti F, Cortesi F, Wolfson AR, Harsh J. The relationship between reported sleep quality and sleep hygiene in Italian and American adolescents. Pediatrics. 2005; 115(Supplement 1): 257-265. https://doi.org/10.1542/peds.2004-0815H
- 18Essner B, Noel M, Myrvik M, Palermo T. Examination of the factor structure of the adolescent sleep–wake scale (ASWS). Behav Sleep Med. 2015; 13(4): 296-307. https://doi.org/10.1080/15402002.2014.896253
- 19Varni JW, Seid M, Kurtin PS. PedsQL™ 4.0: Reliability and validity of the Pediatric Quality of Life Inventory™ Version 4.0 Generic Core Scales in healthy and patient populations. Med Care. 2001; 39(8): 800-812.
- 20Simons LE, Blount RL. Identifying barriers to medication adherence in adolescent transplant recipients. J Pediatr Psychol. 2007; 32(7): 831-844. https://doi.org/10.1093/jpepsy/jsm030
- 21Vandekerckhove M, Cluydts R. The emotional brain and sleep: an intimate relationship. Sleep Med Rev. 2010; 14: 219-226. https://doi.org/10.1016/j.smrv.2010.01.002
- 22Vriend JL, Davidson FD, Corkum PV, Rusak B, Chambers CT, McLaughlin EN. Manipulating sleep duration alters emotional functioning and cognitive performance in children. J Pediatr Psychol. 2013; 38: 1058-1069. https://doi.org/10.1093/jpepsy/jst033
- 23Davis ID, Greenbaum LA, Gipson D, et al. Prevalence of sleep disturbances in children and adolescents with chronic kidney disease. Pediatr Nephrol. 2012; 27: 451-459. https://doi.org/10.1007/s00467-011-2010-y
- 24Daniel L, Kazak AE, Li Y, et al. Relationship between sleep problems and psychological outcomes in adolescent and young adult cancer survivors and controls. Support Care Cancer. 2016; 24: 539-546. https://doi.org/10.1007/s00520-015-2798-2
- 25Lewandowski AS, Ward TM, Palermo TM. Sleep problems in children and adolescents with common medical conditions. Pediatr Clin of North Am. 2011; 58: 699-713. https://doi.org/10.1016/j.pcl.2011.03.012
- 26Lovato N, Gradisar M. A meta-analysis and model of the relationship between sleep and depression in adolescents: recommendations for future research and clinical practice. Sleep Med Rev. 2014; 18: 521-529. https://doi.org/10.1016/j.smrv.2014.03.006
- 27Millman RP, Working Group on Sleepiness in Adolescents/Young Adults, APA Committee on Adolescence. Excessive sleepiness in adolescents and young adults: causes, consequences, and treatment strategies. Pediatrics. 2005; 115: 1774-1786. https://doi.org/10.1542/peds.2005-0772
- 28Gutierrez-Colina AM, Eaton CK, Lee J, et al. Executive functioning, barriers to adherence, and nonadherence in adolescent and young adult transplant recipients. J Pediatr Psychol. 2015; 41: 759-767. https://doi.org/10.1093/jpepsy/jsv107
- 29Simons LE, McCormick ML, Mee LL, Blount RL. Parent and patient perspectives on barriers to medication adherence in adolescent transplant recipients. Pediatr Transplant. 2009; 13: 338-347. https://doi.org/10.1111/j.1399-3046.2008.00940.x
- 30Dewald JF, Meijer AM, Oort FJ, Kerkhof GA, Bogels SM. The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: a meta-analytic review. Sleep Med Rev. 2010; 14: 179-189. https://doi.org/10.1016/j.smrv.2009.10.004
- 31Konen T, Dirk J, Schmiedek F. Cognitive benefits of last night's sleep: daily variations in children's sleep behavior are related to working memory fluctuations. J Child Psychol Psychiatry. 2015; 56: 171-182. https://doi.org/10.1111/jcpp.12296
- 32Lauderdale DS, Knutson KL, Yan LL, Liu K, Rathouz PJ. Self-reported and measured sleep duration: how similar are they? Epidemiology. 2008; 19: 838-845.
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