Acanthamoeba granulomatous amoebic encephalitis after pediatric hematopoietic stem cell transplant
Corresponding Author
Scott L. Coven
Department of Pediatrics, Division of Hematology/Oncology/BMT, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
These authors contributed equally to this work.Correspondence
Scott L. Coven, Department of Pediatrics, Division of Hematology/Oncology/BMT, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.
Email: [email protected]
Search for more papers by this authorEunkyung Song
Department of Pediatrics, Division of Infectious Diseases, Host Defense Program, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
These authors contributed equally to this work.Search for more papers by this authorSarah Steward
Department of Pediatrics, Division of Critical Care, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorChristopher R. Pierson
Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA
Department of Pathology and the Department of Biomedical Education and Anatomy, The Ohio State University College of Medicine, Columbus, OH, USA
Search for more papers by this authorJennifer R. Cope
Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA
Search for more papers by this authorIbne K. Ali
Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA
Search for more papers by this authorMonica I. Ardura
Department of Pediatrics, Division of Infectious Diseases, Host Defense Program, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorMark W. Hall
Department of Pediatrics, Division of Critical Care, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorMelissa G. Chung
Department of Pediatrics, Division of Critical Care, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Department of Pediatrics, Division of Neurology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorRajinder P. S. Bajwa
Department of Pediatrics, Division of Hematology/Oncology/BMT, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorCorresponding Author
Scott L. Coven
Department of Pediatrics, Division of Hematology/Oncology/BMT, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
These authors contributed equally to this work.Correspondence
Scott L. Coven, Department of Pediatrics, Division of Hematology/Oncology/BMT, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.
Email: [email protected]
Search for more papers by this authorEunkyung Song
Department of Pediatrics, Division of Infectious Diseases, Host Defense Program, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
These authors contributed equally to this work.Search for more papers by this authorSarah Steward
Department of Pediatrics, Division of Critical Care, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorChristopher R. Pierson
Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA
Department of Pathology and the Department of Biomedical Education and Anatomy, The Ohio State University College of Medicine, Columbus, OH, USA
Search for more papers by this authorJennifer R. Cope
Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA
Search for more papers by this authorIbne K. Ali
Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA
Search for more papers by this authorMonica I. Ardura
Department of Pediatrics, Division of Infectious Diseases, Host Defense Program, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorMark W. Hall
Department of Pediatrics, Division of Critical Care, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorMelissa G. Chung
Department of Pediatrics, Division of Critical Care, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Department of Pediatrics, Division of Neurology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorRajinder P. S. Bajwa
Department of Pediatrics, Division of Hematology/Oncology/BMT, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA
Search for more papers by this authorAbstract
Acanthamoeba encephalitis is a rare, often fatal condition, particularly after HSCT, with 9 reported cases to date in the world literature. Our case was originally diagnosed with ALL at age 3 years, and after several relapses underwent HSCT at age 9 years. At 17 years of age, he was diagnosed with secondary AML for which he underwent a second allogeneic HSCT. He presented with acute-onset worsening neurological deficits on day +226 after the second transplant and a post-mortem diagnosis of Acanthamoeba encephalitis was established, with the aid of the CDC.
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