Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents
Meerim Park
Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, South Korea
Search for more papers by this authorCorresponding Author
Young Ho Lee
Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, South Korea
Young Ho Lee, Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Wangsimni-ro, 222, Seongdong-gu, Seoul, Korea
Tel.: 82 2 2290 8383
Fax: 82 2 2297 2380
E-mail: [email protected]
Search for more papers by this authorHae-Ryong Kang
Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, South Korea
Search for more papers by this authorJi Won Lee
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorHyoung Jin Kang
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorKyung Duk Park
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorHee Young Shin
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorHyo Seop Ahn
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorHee Jo Baek
Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea
Search for more papers by this authorHoon Kook
Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea
Search for more papers by this authorTai Ju Hwang
Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea
Search for more papers by this authorJae Wook Lee
Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Search for more papers by this authorNack-Gyun Chung
Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Search for more papers by this authorBin Cho
Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Search for more papers by this authorHack-Ki Kim
Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Search for more papers by this authorSoo Hyun Lee
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorKeon Hee Yoo
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorKi Woong Sung
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorHong Hoe Koo
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorKyung Nam Koh
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea
Search for more papers by this authorHo Joon Im
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea
Search for more papers by this authorJong Jin Seo
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea
Search for more papers by this authorJun Eun Park
Department of Pediatrics, Ajou University School of Medicine, Suwon, South Korea
Search for more papers by this authorYeon Jung Lim
Department of Pediatrics, Chungnam National University College of Medicine, Daejon, South Korea
Search for more papers by this authorChuhl Joo Lyu
Department of Pediatrics, Yonsei University, College of Medicine, Seoul, South Korea
Search for more papers by this authorJae Min Lee
Department of Pediatrics, Yeungnam University College of Medicine, Daegu, South Korea
Search for more papers by this authorJeong Ok Hah
Department of Pediatrics, Yeungnam University College of Medicine, Daegu, South Korea
Search for more papers by this authoron behalf of the Korean Cord Blood Transplantation Working Party
Search for more papers by this authorMeerim Park
Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, South Korea
Search for more papers by this authorCorresponding Author
Young Ho Lee
Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, South Korea
Young Ho Lee, Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Wangsimni-ro, 222, Seongdong-gu, Seoul, Korea
Tel.: 82 2 2290 8383
Fax: 82 2 2297 2380
E-mail: [email protected]
Search for more papers by this authorHae-Ryong Kang
Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, South Korea
Search for more papers by this authorJi Won Lee
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorHyoung Jin Kang
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorKyung Duk Park
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorHee Young Shin
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorHyo Seop Ahn
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
Search for more papers by this authorHee Jo Baek
Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea
Search for more papers by this authorHoon Kook
Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea
Search for more papers by this authorTai Ju Hwang
Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea
Search for more papers by this authorJae Wook Lee
Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Search for more papers by this authorNack-Gyun Chung
Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Search for more papers by this authorBin Cho
Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Search for more papers by this authorHack-Ki Kim
Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Search for more papers by this authorSoo Hyun Lee
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorKeon Hee Yoo
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorKi Woong Sung
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorHong Hoe Koo
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorKyung Nam Koh
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea
Search for more papers by this authorHo Joon Im
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea
Search for more papers by this authorJong Jin Seo
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea
Search for more papers by this authorJun Eun Park
Department of Pediatrics, Ajou University School of Medicine, Suwon, South Korea
Search for more papers by this authorYeon Jung Lim
Department of Pediatrics, Chungnam National University College of Medicine, Daejon, South Korea
Search for more papers by this authorChuhl Joo Lyu
Department of Pediatrics, Yonsei University, College of Medicine, Seoul, South Korea
Search for more papers by this authorJae Min Lee
Department of Pediatrics, Yeungnam University College of Medicine, Daegu, South Korea
Search for more papers by this authorJeong Ok Hah
Department of Pediatrics, Yeungnam University College of Medicine, Daegu, South Korea
Search for more papers by this authoron behalf of the Korean Cord Blood Transplantation Working Party
Search for more papers by this author[Correction added on 3rd January 2014, after first online publication: Jae Min Lee has been added to the author's list.]
Abstract
This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II–IV graft-versus-host disease was 32.3%. At a median follow-up of 71 months, five-yr OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%) were lowest in patients with iBMFS. Deaths were mainly due to infection, pulmonary complications, and hemorrhage. In a multivariate analysis, the presence of >3.91 × 105/kg of infused CD34 + cells was the only factor consistently identified as significantly associated with neutrophil engraftment (p = 0.04) and OS (p = 0.03). UCBT using optimal cell doses appears to be a feasible therapy for non-malignant diseases in children and adolescents for whom there is no appropriate HLA-matched related donor. Strategies to reduce transplant-related toxicities would improve the outcomes of UCBT in non-malignant diseases.
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