Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis
Even Herlany Pereira Alves
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Contribution: Data curation, Formal analysis, Investigation, Methodology, Validation, Writing - original draft, Writing - review & editing
Search for more papers by this authorAndré dos Santos Carvalho
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorFelipe Rodolfo Pereira Silva
Department of Morphology, Federal University of Amazonas, Manaus, Brazil
Search for more papers by this authorLuiz Felipe Carvalho França
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorDavid Di Lenardo
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorAny Carolina Cardoso Guimarães Vasconcelos
Medicine School, Education Institute of Parnaiba Valley (FAHESP/ IESVAP - Afya), Parnaíba, PI, Brazil
Search for more papers by this authorHélio Mateus Silva Nascimento
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorVíctor Lucas Ribeiro Lopes
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorJefferson Soares Oliveira
Laboratory of Biochemistry and Biology of Microorganism and Plants (BIOMIC), Federal University of Parnaiba Delta (UFDPar), Parnaíba, PI, Brazil
Search for more papers by this authorCorresponding Author
Daniel Fernando Pereira Vasconcelos
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Correspondence
Daniel Fernando Pereira Vasconcelos, Universidade Federal do Delta do Parnaíba, Campus Ministro Reis Veloso, Colegiado de Biomedicina, Av. São Sebastião, 2819, Reis Veloso, Parnaiba - PI 64204-035, Brazil.
Email: [email protected]
Search for more papers by this authorEven Herlany Pereira Alves
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Contribution: Data curation, Formal analysis, Investigation, Methodology, Validation, Writing - original draft, Writing - review & editing
Search for more papers by this authorAndré dos Santos Carvalho
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorFelipe Rodolfo Pereira Silva
Department of Morphology, Federal University of Amazonas, Manaus, Brazil
Search for more papers by this authorLuiz Felipe Carvalho França
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorDavid Di Lenardo
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorAny Carolina Cardoso Guimarães Vasconcelos
Medicine School, Education Institute of Parnaiba Valley (FAHESP/ IESVAP - Afya), Parnaíba, PI, Brazil
Search for more papers by this authorHélio Mateus Silva Nascimento
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorVíctor Lucas Ribeiro Lopes
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Search for more papers by this authorJefferson Soares Oliveira
Laboratory of Biochemistry and Biology of Microorganism and Plants (BIOMIC), Federal University of Parnaiba Delta (UFDPar), Parnaíba, PI, Brazil
Search for more papers by this authorCorresponding Author
Daniel Fernando Pereira Vasconcelos
Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, PI, Brazil
Correspondence
Daniel Fernando Pereira Vasconcelos, Universidade Federal do Delta do Parnaíba, Campus Ministro Reis Veloso, Colegiado de Biomedicina, Av. São Sebastião, 2819, Reis Veloso, Parnaiba - PI 64204-035, Brazil.
Email: [email protected]
Search for more papers by this authorAbstract
Objective
The objective of this research was to evaluate the effects of bromelain (derived from Ananas comosus) upon periodontitis in rats.
Materials and Methods
Twenty-four rats were separated into groups: control, periodontitis, and bromelain treatment. Bromelain was administered daily by intraperitoneal injection for 20 days. Periodontitis was induced by ligature around the first molars. Oral parameters and blood biomarkers were measured. The histopathological evaluation of the hepatic tissue was performed. Bromelain treatment significantly reduced several oral inflammatory parameters, alveolar bone loss, and blood biomarkers compared to the rats on periodontitis.
Results
Treatment with bromelain improved the steatosis score. Bromelain used in ligature-induced periodontitis in rats was able to reduce the oral inflammatory parameters Gingival Bleeding Index (GBI), tooth mobility (TM), probing pocket depth (PPD), malondialdehyde (MDA), alveolar bone height (ABH) and gingival myeloperoxidase (MPO) and blood parameters (cholesterol, triglycerides, alanine aminotransferase, and aspartate aminotransferase). Bromelain treatment reduced the impact of periodontitis, such as the reduction of hepatic steatosis and improvement in the dosages of MDA and GSH.
Conclusion
Bromelain acts as a potential adjunct in the non-surgical treatment of periodontitis and, consequently, reduces the impact of periodontitis, acting as anti-inflammatory and antioxidant.
CONFLICT OF INTEREST
The authors declare that there is no conflict of interest.
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