Pharmacological management of narcolepsy in children and adolescents
Corresponding Author
Giuseppe Plazzi
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
University of Modena and Reggio Emilia, Modena, Italy
Correspondence
Giuseppe Plazzi, Ospedale Bellaria, Padiglione G, Primo Piano, Via Altura 3, 40,139, Bologna, Italy.
Email: [email protected]
Contribution: Conceptualization, Writing - original draft, Supervision, Validation
Search for more papers by this authorFabio Pizza
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy
Contribution: Validation, Conceptualization, Writing - original draft, Supervision
Search for more papers by this authorMichel Lecendreux
Pediatric Sleep Disorders Center, AP-HP, Robert Debre Hospital, Paris, France
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome, Paris, France
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorPaul Gringras
Children's Sleep Medicine Kings College, London, UK
Contribution: Conceptualization, Supervision, Validation, Writing - original draft
Search for more papers by this authorLucie Barateau
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France
Institute of Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France
Contribution: Conceptualization, Validation, Supervision, Writing - original draft
Search for more papers by this authorOliviero Bruni
Department of Developmental and Social Psychology, Sapienza University, Rome, Italy
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorPatricia Franco
Pediatric Sleep Unit and National Reference Center for Narcolepsy, Mother-Children's Hospital, Hospices Civils de Lyon & U1028, Lyon Neuroscience Research Center (CRNL), University Lyon 1, Lyon, France
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome Lyon, Lyon, France
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorAlex Iranzo
Neurology Service, Sleep Disorders Centre, Hospital Clínic Barcelona, Universitat de Barcelona. IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain
Contribution: Supervision, Conceptualization, Writing - original draft, Validation
Search for more papers by this authorPoul Jennum
Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen, Denmark
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorRamin Khatami
Center for Sleep Medicine, Sleep Research and Epileptology, Clinic Barmelweid AG, Barmelweid, Switzerland
Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
Contribution: Supervision, Conceptualization, Writing - original draft, Validation
Search for more papers by this authorStine Knudsen-Heier
Norwegian Center for Neurodevelopmental Disorders and Hypersomnias – NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Contribution: Validation, Supervision, Conceptualization, Writing - original draft
Search for more papers by this authorSilvia Miano
Neurocenter of Southern Switzerland, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Sleep Medicine Unit, Civic Hospital, Lugano, Switzerland
Contribution: Validation, Supervision, Conceptualization, Writing - original draft
Search for more papers by this authorLino Nobili
Child Neuropsychiatry Unit, IRCCS Istituto G. Gaslini, Genoa, Italy
Department of Neuroscience – Rehabilitation – Ophthalmology – Genetics – Child and Maternal Health (DINOGMI), University of Genova, Genoa, Italy
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorMarkku Partinen
Department of Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland
Helsinki Sleep Clinic, Terveystalo Healthcare, Helsinki, Finland
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorPaul Reading
Department of Neurology, The James Cook University Hospital, Middlesbrough, UK
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorKarel Sonka
Department of Neurology and Center for Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorAttila Szakacs
Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Pediatrics, Halmstad County Hospital, Halmstad, Sweden
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorMassimo Zenti
Associazione Italiana Narcolettici e Ipersonni, Florence, Italy
European Narcolepsy Alliance for Patients, Bruxells, Belgium
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorUlf Kallweit
Center for Narcolepsy and Hypersomnias, Professorship for Narcolepsy and Hypersomnolence Research, Department of Medicine, University Witten/Herdecke, Witten, Germany
Center for Biomedical Education and Research (ZBAF), University Witten/Herdecke, Witten, Germany
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorGert J. Lammers
Stichting Epilepsie Instellingen Nederland (SEIN), Sleep–Wake Center, Heemstede, Netherlands
Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands
Contribution: Writing - original draft, Conceptualization, Validation, Supervision
Search for more papers by this authorYves Dauvilliers
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France
Institute of Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France
Contribution: Conceptualization, Validation, Writing - original draft, Supervision
Search for more papers by this authorClaudio L. A. Bassetti
Medical Faculty, University of Bern, Bern, Switzerland
Department of Neurology, University Hospital (Inselspital), Bern, Switzerland
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorCorresponding Author
Giuseppe Plazzi
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
University of Modena and Reggio Emilia, Modena, Italy
Correspondence
Giuseppe Plazzi, Ospedale Bellaria, Padiglione G, Primo Piano, Via Altura 3, 40,139, Bologna, Italy.
Email: [email protected]
Contribution: Conceptualization, Writing - original draft, Supervision, Validation
Search for more papers by this authorFabio Pizza
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy
Contribution: Validation, Conceptualization, Writing - original draft, Supervision
Search for more papers by this authorMichel Lecendreux
Pediatric Sleep Disorders Center, AP-HP, Robert Debre Hospital, Paris, France
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome, Paris, France
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorPaul Gringras
Children's Sleep Medicine Kings College, London, UK
Contribution: Conceptualization, Supervision, Validation, Writing - original draft
Search for more papers by this authorLucie Barateau
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France
Institute of Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France
Contribution: Conceptualization, Validation, Supervision, Writing - original draft
Search for more papers by this authorOliviero Bruni
Department of Developmental and Social Psychology, Sapienza University, Rome, Italy
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorPatricia Franco
Pediatric Sleep Unit and National Reference Center for Narcolepsy, Mother-Children's Hospital, Hospices Civils de Lyon & U1028, Lyon Neuroscience Research Center (CRNL), University Lyon 1, Lyon, France
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome Lyon, Lyon, France
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorAlex Iranzo
Neurology Service, Sleep Disorders Centre, Hospital Clínic Barcelona, Universitat de Barcelona. IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain
Contribution: Supervision, Conceptualization, Writing - original draft, Validation
Search for more papers by this authorPoul Jennum
Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen, Denmark
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorRamin Khatami
Center for Sleep Medicine, Sleep Research and Epileptology, Clinic Barmelweid AG, Barmelweid, Switzerland
Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
Contribution: Supervision, Conceptualization, Writing - original draft, Validation
Search for more papers by this authorStine Knudsen-Heier
Norwegian Center for Neurodevelopmental Disorders and Hypersomnias – NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Contribution: Validation, Supervision, Conceptualization, Writing - original draft
Search for more papers by this authorSilvia Miano
Neurocenter of Southern Switzerland, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Sleep Medicine Unit, Civic Hospital, Lugano, Switzerland
Contribution: Validation, Supervision, Conceptualization, Writing - original draft
Search for more papers by this authorLino Nobili
Child Neuropsychiatry Unit, IRCCS Istituto G. Gaslini, Genoa, Italy
Department of Neuroscience – Rehabilitation – Ophthalmology – Genetics – Child and Maternal Health (DINOGMI), University of Genova, Genoa, Italy
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorMarkku Partinen
Department of Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland
Helsinki Sleep Clinic, Terveystalo Healthcare, Helsinki, Finland
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorPaul Reading
Department of Neurology, The James Cook University Hospital, Middlesbrough, UK
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorKarel Sonka
Department of Neurology and Center for Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorAttila Szakacs
Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Pediatrics, Halmstad County Hospital, Halmstad, Sweden
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorMassimo Zenti
Associazione Italiana Narcolettici e Ipersonni, Florence, Italy
European Narcolepsy Alliance for Patients, Bruxells, Belgium
Contribution: Supervision, Validation, Conceptualization, Writing - original draft
Search for more papers by this authorUlf Kallweit
Center for Narcolepsy and Hypersomnias, Professorship for Narcolepsy and Hypersomnolence Research, Department of Medicine, University Witten/Herdecke, Witten, Germany
Center for Biomedical Education and Research (ZBAF), University Witten/Herdecke, Witten, Germany
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorGert J. Lammers
Stichting Epilepsie Instellingen Nederland (SEIN), Sleep–Wake Center, Heemstede, Netherlands
Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands
Contribution: Writing - original draft, Conceptualization, Validation, Supervision
Search for more papers by this authorYves Dauvilliers
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France
Institute of Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France
Contribution: Conceptualization, Validation, Writing - original draft, Supervision
Search for more papers by this authorClaudio L. A. Bassetti
Medical Faculty, University of Bern, Bern, Switzerland
Department of Neurology, University Hospital (Inselspital), Bern, Switzerland
Contribution: Conceptualization, Writing - original draft, Validation, Supervision
Search for more papers by this authorOpen Research
DATA AVAILABILITY STATEMENT
No data reported.
REFERENCES
- Bassetti, C. L. A., Kallweit, U., Vignatelli, L., Plazzi, G., Lecendreux, M., Baldin, E., Dolenc-Groselj, L., Jennum, P., Khatami, R., Manconi, M., Mayer, G., Partinen, M., Pollmächer, T., Reading, P., Santamaria, J., Sonka, K., Dauvilliers, Y., & Lammers, G. J. (2021). European guideline and expert statements on the management of narcolepsy in adults and children. European Journal of Neurology, 28, 2815–2830.
- Dauvilliers, Y., Lecendreux, M., Lammers, G. J., Franco, P., Poluektov, M., Caussé, C., Lecomte, I., Lecomte, J.-M., Lehert, P., Schwartz, J.-C., & Plazzi, G. (2023). Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: A double-blind, randomised, placebo-controlled trial. Lancet Neurology, 22, 303–311.
- Lecendreux, M., Bruni, O., Franco, P., Gringras, P., Konofal, E., Nevsimalova, S., Paiva, T., Partinen, M., Peeters, E., Peraita-Adrados, R., Plazzi, G., & Poli, F. (2012). Clinical experience suggests that modafinil is an effective and safe treatment for paediatric narcolepsy. Journal of Sleep Research, 21(4), 481–483.
- Plazzi, G., Clawges, H. M., & Owens, J. A. (2018). Clinical characteristics and burden of illness in pediatric patients with narcolepsy. Pediatric Neurology, 85, 21–32.
- Postiglione, E., Antelmi, E., Pizza, F., Lecendreux, M., Dauvilliers, Y., & Plazzi, G. (2018). The clinical spectrum of childhood narcolepsy. Sleep Medicine Reviews, 38, 70–85.
- Triller, A., Pizza, F., Lecendreux, M., Lieberich, L., Rezaei, R., Pech de Laclause, A., Vandi, S., Plazzi, G., & Kallweit, U. (2023). Real-world treatment of pediatric narcolepsy with pitolisant: A retrospective, multicenter study. Sleep Medicine, 103, 62–68.
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