Effect of different anti-cardiovascular disease treatments on the severity of obstructive sleep apnea
Ruihan Lin
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Ruihan Lin and Yuan Zhang contributed equally to this work and are co-first authors.
Search for more papers by this authorCorresponding Author
Yuan Zhang
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Ruihan Lin and Yuan Zhang contributed equally to this work and are co-first authors.
Correspondence
Yuan Zhang and Minhan Yi, Central South University, Changsha, Hunan, China.
Email: [email protected]; [email protected]
Search for more papers by this authorWenjie Yan
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Search for more papers by this authorWenru Hu
Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Search for more papers by this authorYuwei Chen
Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Search for more papers by this authorCorresponding Author
Minhan Yi
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
School of Life Sciences, Central South University, Changsha, Hunan, China
Correspondence
Yuan Zhang and Minhan Yi, Central South University, Changsha, Hunan, China.
Email: [email protected]; [email protected]
Search for more papers by this authorRuihan Lin
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Ruihan Lin and Yuan Zhang contributed equally to this work and are co-first authors.
Search for more papers by this authorCorresponding Author
Yuan Zhang
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Ruihan Lin and Yuan Zhang contributed equally to this work and are co-first authors.
Correspondence
Yuan Zhang and Minhan Yi, Central South University, Changsha, Hunan, China.
Email: [email protected]; [email protected]
Search for more papers by this authorWenjie Yan
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Search for more papers by this authorWenru Hu
Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Search for more papers by this authorYuwei Chen
Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Search for more papers by this authorCorresponding Author
Minhan Yi
Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
School of Life Sciences, Central South University, Changsha, Hunan, China
Correspondence
Yuan Zhang and Minhan Yi, Central South University, Changsha, Hunan, China.
Email: [email protected]; [email protected]
Search for more papers by this authorSummary
Obstructive sleep apnea (OSA) and cardiovascular co-morbidities have a mutually reinforcing effect, but existing studies have focussed only on the improvement of the associated co-morbidities by treatment for OSA. To provide fresh guidelines for the treatment of OSA from a co-morbidity standpoint, we conducted a systematic search of Web of Science, PubMed, EMBASE, and the Cochrane Library for articles published from inception up to 2 May 2023. Fourteen original studies of patients with OSA with cardiovascular co-morbidities and who received related treatment were included in the analysis. We found that diuretic treatment can reduce the apnea–hypopnea index in patients with OSA and hypertension (−19.41/h, p = 1.0 × 10−5), aldosterone-angiotensin inhibitors also have a 9.19/h reduction (p = 0.003), while the effect of renal sympathetic denervation is insignificant (−2.32/h, p = 0.19). The short-term treatment (<4 weeks) did not show an improvement (−2.72/h, p = 0.16), while long-term treatment (>4 weeks) produced surprising outcomes (−12.78/h, p = 0.002). Patients with milder disease (baseline AHI < 35/h) had insignificant improvements (−1.05/h, p = 0.46), whereas those with more severe disease (baseline AHI > 35/h) could achieve satisfactory outcomes (−14.74/h, p < 0.00001). In addition, it also showed some improvement in the oxygen desaturation index and blood oxygen. Our results support the additional benefit of antihypertensive treatment for OSA symptoms, and the efficacy can be affected by different therapy, treatment duration, and severity levels. It could be useful in developing clinical therapy, educating patients, and exploring interaction mechanisms. The proposal was registered with PROSPERO (CRD42022351206).
CONFLICT OF INTEREST STATEMENT
The authors declare no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
All data generated or analysed during this study are included in this published article and its supplementary information files.
Supporting Information
| Filename | Description |
|---|---|
| jsr13965-sup-0001-Supinfo01.pdfPDF document, 325 KB | DATA S1. Supplementary Tables. |
| jsr13965-sup-0002-Supinfo02.pdfPDF document, 825.7 KB | DATA S2. Supplementary Figures. |
| jsr13965-sup-0003-Supinfo03.pdfPDF document, 69.2 KB | DATA S3. PRISMA checklist. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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