Cardiac injury and vasoplegia in critically ill children due to multisystem inflammatory syndrome in children associated with COVID-19
Corresponding Author
Andreia D Constante
Pediatric Cardiology Department, Hospital de Santa Marta, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Pediatric Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Correspondence: Dr Andreia D Constante, Pediatric Cardiology Department, Hospital de Santa Marta, Centro Hospitalar e Universitário de Lisboa Central, Rua de Santa Marta, 1169-024 Lisboa, Portugal. Fax: +35121 3594034; email: [email protected]
Search for more papers by this authorAna M Garcia
Pediatric Infectious Diseases Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorIsabel C Pataca
Pediatric Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorInês Salva
Pediatric Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorConceição Trigo
Pediatric Cardiology Department, Hospital de Santa Marta, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorMaria J Brito
Pediatric Infectious Diseases Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorCorresponding Author
Andreia D Constante
Pediatric Cardiology Department, Hospital de Santa Marta, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Pediatric Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Correspondence: Dr Andreia D Constante, Pediatric Cardiology Department, Hospital de Santa Marta, Centro Hospitalar e Universitário de Lisboa Central, Rua de Santa Marta, 1169-024 Lisboa, Portugal. Fax: +35121 3594034; email: [email protected]
Search for more papers by this authorAna M Garcia
Pediatric Infectious Diseases Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorIsabel C Pataca
Pediatric Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorInês Salva
Pediatric Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorConceição Trigo
Pediatric Cardiology Department, Hospital de Santa Marta, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorMaria J Brito
Pediatric Infectious Diseases Unit, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
Search for more papers by this authorConflict of interest: None declared.
References
- 1 World Health Organization. Multisystem Inflammatory Syndrome in Children and Adolescents with COVID-19. 2020. Available from: https://www.who.int/publications-detail/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19 [accessed 22 May 2020].
- 2Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395: 1607–8.
- 3Ammirati E, Wang DW. SARS-CoV-2 inflames the heart. The importance of awareness of myocardial injury in COVID-19 patients. Int. J. Cardiol. 2020; 311: 122–3.
- 4 European Society of Cardiology. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. 2020. Available from: https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance [accessed 15 June 2020].
- 5Jose RJ, Manuel A. COVID-19 cytokine storm: The interplay between inflammation and coagulation. Lancet Respir. Med. 2020; 8: e46–7.
- 6Lambden S, Creagh-Brown BC, Hunt J, Summers C, Forni LG. Definitions and pathophysiology of vasoplegic shock. Crit. Care 2018; 22: 174.
- 7Belhadjer Z, Méot M, Bajolle F et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation 2020; 142: 429–36.
- 8Cheung EW, Zachariah P, Gorelik M et al. Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents in New York City. JAMA 2020; 324: 294–6.
- 9Hennon TR, Penque MD, Abdul-Aziz R et al. COVID-19 associated multisystem inflammatory syndrome in children (MIS-C) guidelines; a Western New York approach. Prog. Pediatr. Cardiol. 2020: 101232. Epub ahead of print.
- 10Sankar J, Dhochak N, Kabra SK, Lodha R. COVID-19 in children: Clinical approach and management. Indian J. Pediatr. 2020; 87: 433–42.
- 11Panigada M, Bottino N, Tagliabue P et al. Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis. J. Thromb. Haemost. 2020; 18: 1738–42.
- 12Sperotto F, Friedman KG, Son MBF, VanderPluym CJ, Newburger JW, Dionne A. Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: A comprehensive review and proposed clinical approach. Eur. J. Pediatr. 2021; 180: 307–22.
