Volume 31, Issue 3 pp. 602-608

Clinical Investigative Study

Dentate Nucleus Signal Intensity Changes in Children with Adrenoleukodystrophy in Comparison to Primary Brain Tumor with and without Radiotherapy after Gadobutrol Administration

Kerem Ozturk,

Corresponding Author

Kerem Ozturk

[email protected]

orcid.org/0000-0001-9664-2347

Department of Radiology, University of Minnesota Health, Minneapolis, MN

Correspondence

Kerem Ozturk, MD, Neuroradiology Fellow, Department of Radiology, University of Minnesota Health, 420 Delaware Street S.E. B226, Mayo Memorial Building MMC 292, Minneapolis, MN 55455.

Email: [email protected]

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David Nascene,

David Nascene

orcid.org/0000-0002-2468-7359

Department of Radiology, University of Minnesota Health, Minneapolis, MN

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Kerem Ozturk,

Corresponding Author

Kerem Ozturk

[email protected]

orcid.org/0000-0001-9664-2347

Department of Radiology, University of Minnesota Health, Minneapolis, MN

Correspondence

Kerem Ozturk, MD, Neuroradiology Fellow, Department of Radiology, University of Minnesota Health, 420 Delaware Street S.E. B226, Mayo Memorial Building MMC 292, Minneapolis, MN 55455.

Email: [email protected]

Search for more papers by this author

David Nascene,

David Nascene

orcid.org/0000-0002-2468-7359

Department of Radiology, University of Minnesota Health, Minneapolis, MN

Search for more papers by this author

First published: 30 March 2021

https://doi.org/10.1111/jon.12844

Citations: 1

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ABSTRACT

Background and Purpose

To determine whether cerebral adrenoleukodystrophy (cALD) or brain irradiation in patients with primary brain tumor affects T1-weighted imaging (T1WI) signal intensity (SI) of the dentate nucleus (DN) in a pediatric cohort who had received consecutive macrocyclic gadolinium-based contrast agent (mcGBCA) gadobutrol.

Methods

This study included 97 pediatric patients who underwent mcGBCA-enhanced MRI from 2010 to 2020 (29 children with primary brain tumors without brain radiation therapy [mcGBCA group-1], 33 children with primary brain tumors and radiation treatment [mcGBCA group-2], 35 children with cALD [mcGBCA group-3], and 97 sex-/age-matched control subjects [subgroups matched to each of the three subject groups] without GBCA administration). The DN-to-middle cerebellar peduncle (MCP) SI ratios on T1WI were then determined. A paired t-test was performed to compare SI ratios between children exposed to mcGBCA in each group and control subjects. The relationships between SI ratios and confounding variables were analyzed utilizing the Pearson correlation analysis.

Results

The DN-to-MCP SI ratio was significantly higher of mcGBCA group-2 (1.046±.071) or mcGBCA group-3 (.972±.038) than in the control group-2 (.983±.041, P<.001) and control group-3 (.937±.051, P = .002), respectively, but no significant difference of the SI ratio was noted between mcGBCA group-1 (.984±.032) and control-group-1 (.982±.035, P = .860). No significant correlation was noted between SI ratio values and the cumulative dose or number of mcGBCA administrations, age, or the elapsed time between the MRI examinations (all P>.05).

Conclusions

Hyperintense T1WI signal in the DN may be seen in children with brain tumors undergoing brain irradiation, as well as in children with cALD.

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Citing Literature

Volume31, Issue3

May/June 2021

Pages 602-608

Dentate Nucleus Signal Intensity Changes in Children with Adrenoleukodystrophy in Comparison to Primary Brain Tumor with and without Radiotherapy after Gadobutrol Administration

ABSTRACT

Background and Purpose

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

Information

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Dentate Nucleus Signal Intensity Changes in Children with Adrenoleukodystrophy in Comparison to Primary Brain Tumor with and without Radiotherapy after Gadobutrol Administration

ABSTRACT

Background and Purpose

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

Related

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