Review Article
Recovery of Hibernating Myocardium: What Is the Role of Surgical Revascularization?
Christopher T. Holley M.D.,
Eric K. Long Ph.D.,
Megan E. Lindsey B.S.,
Edward O. McFalls M.D. Ph.D,
Rosemary F. Kelly M.D.,
Christopher T. Holley M.D.
Department of Surgery, University of Minnesota, Minneapolis, Minnesota
Search for more papers by this authorEric K. Long Ph.D.
Department of Surgery, University of Minnesota, Minneapolis, Minnesota
Search for more papers by this authorMegan E. Lindsey B.S.
College of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota
Search for more papers by this authorEdward O. McFalls M.D. Ph.D
Department of Cardiology, Minneapolis Veterans Affairs Health Care System (VACHS), Minneapolis, Minnesota
Search for more papers by this authorCorresponding Author
Rosemary F. Kelly M.D.
Department of Surgery, University of Minnesota, Minneapolis, Minnesota
Department of Cardiothoracic Surgery, VACHS, Minneapolis, Minnesota
Address for correspondence: Rosemary F. Kelly, M.D., 1 Veterans Drive, Minneapolis, MN 55417. Fax: 612-725-1920; e-mail: [email protected]
Search for more papers by this authorChristopher T. Holley M.D.,
Eric K. Long Ph.D.,
Megan E. Lindsey B.S.,
Edward O. McFalls M.D. Ph.D,
Rosemary F. Kelly M.D.,
Christopher T. Holley M.D.
Department of Surgery, University of Minnesota, Minneapolis, Minnesota
Search for more papers by this authorEric K. Long Ph.D.
Department of Surgery, University of Minnesota, Minneapolis, Minnesota
Search for more papers by this authorMegan E. Lindsey B.S.
College of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota
Search for more papers by this authorEdward O. McFalls M.D. Ph.D
Department of Cardiology, Minneapolis Veterans Affairs Health Care System (VACHS), Minneapolis, Minnesota
Search for more papers by this authorCorresponding Author
Rosemary F. Kelly M.D.
Department of Surgery, University of Minnesota, Minneapolis, Minnesota
Department of Cardiothoracic Surgery, VACHS, Minneapolis, Minnesota
Address for correspondence: Rosemary F. Kelly, M.D., 1 Veterans Drive, Minneapolis, MN 55417. Fax: 612-725-1920; e-mail: [email protected]
Search for more papers by this authorConflict of interest: The authors acknowledge no conflict of interest in the submission.
Abstract
Myocardial responses to chronic ischemia represent a continuum of adaptations resulting, over time, in a stress-resistant phenotype. One such adaptation, hibernating myocardium (HM), has increased antioxidant capacity that protects against ischemia-induced oxidative stress. Studies have suggested that revascularization alone may not fully restore cardiac function, highlighting the need for targeted therapies to serve as adjuncts to the innate healing process following revascularization. In our review, we discuss current understanding of HM and the recovery process following surgical revascularization, focusing on animal models of HM to understand implications for human patients. doi: 10.1111/jocs.12477 (J Card Surg 2015;30:224–231)
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