ORIGINAL ARTICLE
Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial
Zeliha Betul Ozsagir,
Ebru Saglam,
Berza Sen Yilmaz,
Joseph Choukroun,
Mustafa Tunali,
Corresponding Author
Zeliha Betul Ozsagir
Department of Periodontology, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey
Correspondence
Zeliha Betul Ozsagir, Department of Periodontology, Faculty of Dentistry, Bezmialem University, Istanbul, Turkey
Email: [email protected]
Search for more papers by this authorEbru Saglam
Department of Periodontology, Faculty of Dentistry, University of Health Science, Istanbul, Turkey
Search for more papers by this authorBerza Sen Yilmaz
Department of Orthodontics, Faculty of Dentistry, Bezmialem University, Istanbul, Turkey
Search for more papers by this authorJoseph Choukroun
FORM, Frankfurt Oral Regenerative Medicine, Clinic for Maxillofacial and Plastic Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Search for more papers by this authorMustafa Tunali
Department of Periodontology, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey
Search for more papers by this authorZeliha Betul Ozsagir,
Ebru Saglam,
Berza Sen Yilmaz,
Joseph Choukroun,
Mustafa Tunali,
Corresponding Author
Zeliha Betul Ozsagir
Department of Periodontology, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey
Correspondence
Zeliha Betul Ozsagir, Department of Periodontology, Faculty of Dentistry, Bezmialem University, Istanbul, Turkey
Email: [email protected]
Search for more papers by this authorEbru Saglam
Department of Periodontology, Faculty of Dentistry, University of Health Science, Istanbul, Turkey
Search for more papers by this authorBerza Sen Yilmaz
Department of Orthodontics, Faculty of Dentistry, Bezmialem University, Istanbul, Turkey
Search for more papers by this authorJoseph Choukroun
FORM, Frankfurt Oral Regenerative Medicine, Clinic for Maxillofacial and Plastic Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Search for more papers by this authorMustafa Tunali
Department of Periodontology, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey
Search for more papers by this authorClinicalTrials.gov NCT03274674
Funding
This work was supported by Bezmialem Vakif University Scientific Research Projects (protocol number: 6.2017/18), Istanbul, Turkey.
Abstract
Aim
The aim of this present study was to evaluate the effect of gingival thickness (GT) and keratinized tissue width (KTW) using injectable platelet-rich fibrin (i-PRF) alone and with microneedling (MN) in individuals with thin periodontal phenotypes.
Materials and Methods
In this split-mouth study, 33 systemically healthy patients with thin periodontal phenotypes were randomly treated with MN + i-PRF and i-PRF. I-PRF was injected on one side, and MN + i-PRF was performed on the other side of the same patient at 4 sessions with 10-day intervals. Clinical periodontal measurements, GT and KTW were assessed before the treatment and every month for six months after the final injection.
Results
After the evaluation of GT between the groups, a statistically significant difference was found in MN + i-PRF group at the sixth month. In the intra-group comparisons, a statistically significant increase in GT was observed within both i-PRF [from 0.43 mm ± 0.14 to 0.62 mm ± 0.11 (p < .001)] and MN + i-PRF [from 0.4 mm ± 0.14 to 0.66 mm ± 0.12 (p < .001)] groups at the sixth month.
Conclusions
In individuals with thin periodontal phenotypes, standalone i-PRF and i-PRF with MN may have an influence in increasing GT. The results suggest that application of i-PRF and MN may be a first step of non-surgical method for increasing gingival thickness.
CONFLICT OF INTEREST
The authors have no financial or personal relationships with other people or organizations to declare.
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