Salivary antimicrobial defensins in pregnancy
Corresponding Author
Mervi Gürsoy
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Address:
Mervi Gürsoy
Department of Periodontology
Institute of Dentistry
University of Turku
Lemminkäisenkatu 2, FI-20520 Turku
Finland
E-mail: [email protected]
Search for more papers by this authorUlvi K. Gürsoy
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Search for more papers by this authorAnna Liukkonen
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Search for more papers by this authorTommi Kauko
Department of Biostatistics, University of Turku, Turku, Finland
Search for more papers by this authorSaara Penkkala
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Search for more papers by this authorEija Könönen
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Oral Health Care, Welfare Division, City of Turku, Turku, Finland
Search for more papers by this authorCorresponding Author
Mervi Gürsoy
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Address:
Mervi Gürsoy
Department of Periodontology
Institute of Dentistry
University of Turku
Lemminkäisenkatu 2, FI-20520 Turku
Finland
E-mail: [email protected]
Search for more papers by this authorUlvi K. Gürsoy
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Search for more papers by this authorAnna Liukkonen
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Search for more papers by this authorTommi Kauko
Department of Biostatistics, University of Turku, Turku, Finland
Search for more papers by this authorSaara Penkkala
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Search for more papers by this authorEija Könönen
Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland
Oral Health Care, Welfare Division, City of Turku, Turku, Finland
Search for more papers by this authorConflict of interest and source of funding statement
The authors declare no financial or commercial conflict of interest.
This work was supported by grants from the Finnish Dental Society Apollonia (MG, AL).
Abstract
Aim
Susceptibility to and severity of gingival inflammation are enhanced during pregnancy; however, regulation of oral innate immune response, including antimicrobial peptides, during pregnancy is still unknown. We analysed salivary levels of human beta-defensin (hBD)-1, -2, -3, and human neutrophil peptide (HNP)-1 in pregnant women, and related those to their periodontal status.
Material and Methods
In this cohort study, 30 generally healthy, non-smoking Caucasian women without periodontitis were followed at three time points during pregnancy and twice post-partum. The non-pregnant group consisted of 24 women, who were examined three times at the following months. At each visit, periodontal status was recorded and stimulated saliva samples were collected. Salivary estradiol, progesterone, and defensin concentrations were measured by ELISA assays.
Results
After adjusting for visible plaque and gingival bleeding, reduced salivary concentrations of hBD-1, hBD-2, and HNP-1 were found especially during the third trimester, whereas hBD-3 concentrations did not change during pregnancy and post-partum visits. Weak associations were observed between salivary defensin and hormone concentrations and clinical parameters.
Conclusion
There seems to be an independent regulation cascade for each antimicrobial defensin in the oral cavity during pregnancy, despite of the similarities between these antimicrobial peptides.
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