Long-Term Follow-Up of Pure Linear Ablation for Persistent Atrial Fibrillation Without Circumferential Pulmonary Vein Isolation
LINGMIN WU M.D.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Search for more papers by this authorCorresponding Author
YAN YAO M.D., Ph.D., F.H.R.S.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Address for correspondence: Yan Yao, M.D., Ph.D., F.H.R.S., Fuwai Hospital and Cardiovascular Institute, 167 Beilishi Road, Xicheng, Beijing 100037, China. Fax: +86-6024-1570; E-mail: [email protected]Search for more papers by this authorLIHUI ZHENG M.D., Ph.D.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Search for more papers by this authorKUIJUN ZHANG M.D.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Search for more papers by this authorSHU ZHANG M.D., Ph.D.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Search for more papers by this authorLINGMIN WU M.D.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Search for more papers by this authorCorresponding Author
YAN YAO M.D., Ph.D., F.H.R.S.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Address for correspondence: Yan Yao, M.D., Ph.D., F.H.R.S., Fuwai Hospital and Cardiovascular Institute, 167 Beilishi Road, Xicheng, Beijing 100037, China. Fax: +86-6024-1570; E-mail: [email protected]Search for more papers by this authorLIHUI ZHENG M.D., Ph.D.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Search for more papers by this authorKUIJUN ZHANG M.D.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Search for more papers by this authorSHU ZHANG M.D., Ph.D.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Search for more papers by this authorNo disclosures.
Long-Term Follow-Up of Linear Ablation for AF
Background
The long-term outcome of radiofrequency catheter ablation in persistent atrial fibrillation (AF) patients remains controversial due to different procedural strategies. This study aimed to present the clinical outcome of a pure linear ablation approach without circumferential pulmonary vein isolation (CPVI) over an extended (>5 years) follow-up period.
Methods
From January 2005 to December 2009, 120 consecutive patients (94 men; age, 53.6 ± 10.3 years) with drug-refractory persistent AF that underwent pure linear ablation using AF termination as the desired procedural endpoint were enrolled.
Results
In the primary procedure, sinus rhythm was restored by ablation in 75 (62.5%) patients, and the remaining 45 patients in whom AF could not be terminated by ablation received electrical cardioversion. During a median follow-up period of 5.1 (range 3.2–7.5) years, sinus rhythm was maintained in 48 (40.0%) patients without any antiarrhythmic drugs after a single procedure. There was a higher long-term success in the patients in whom AF was terminated by ablation than in those requiring cardioversion (49.3 vs. 24.4%; P = 0.007).
Conclusion
Linear catheter ablation without CPVI is effective for persistent AF. Patients with AF terminated by ablation were associated with a better long-term outcome than those requiring cardioversion
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