Volume 64, Issue 3 pp. 413-419

Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus

BeiBei Zhang,

BeiBei Zhang

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

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AiLi Cao,

AiLi Cao

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

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JiYan Zhou,

JiYan Zhou

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

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ZhiBi Hu,

ZhiBi Hu

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

Shanghai Key Laboratory of Complex Prescription

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DaZheng Wu,

Corresponding Author

DaZheng Wu

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

Shanghai Key Laboratory of Complex Prescription

E-Institute of TCM Internal Medicine, Shanghai Municipal Education Commission, Shanghai, China

DaZheng Wu, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. E-mail: [email protected]Search for more papers by this author

BeiBei Zhang,

BeiBei Zhang

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

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AiLi Cao,

AiLi Cao

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

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JiYan Zhou,

JiYan Zhou

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

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ZhiBi Hu,

ZhiBi Hu

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

Shanghai Key Laboratory of Complex Prescription

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DaZheng Wu,

Corresponding Author

DaZheng Wu

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

Shanghai Key Laboratory of Complex Prescription

E-Institute of TCM Internal Medicine, Shanghai Municipal Education Commission, Shanghai, China

First published: 13 November 2011

https://doi.org/10.1111/j.2042-7158.2011.01407.x

Citations: 26

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Abstract

Objectives Postoperative ileus is major cause of postoperative complication and prolonged hospitalization. Jatrorrhizine, which is a protoberberine alkaloid isolated from the medicinal plants Berberis aristata and Coptis chinensis, has been found to increase contractility of gastric antral and ileum smooth muscles of rat gastrointestinal tract. We have investigated whether jatrorrhizine could offset gastrointestinal transit in rat with postoperative ileus.

Methods Postoperative ileus was induced by laparotomy with intestinal manipulation under anaesthesia. Gastrointestinal transit was evaluated by measurement of gastric emptying, geometric centre and the migration of Evans blue.

Key findings Postoperative ileus significantly delayed gastric emptying and intestinal transit. Jatrorrhizine dose-dependently (0.1, 0.3 and 1 mg/kg) offset delayed gastric emptying and intestinal transit (geometric centre and the migration of Evans blue) in postoperative ileus. Pretreatment of animals with atropine inhibited the action of jatrorrhizine on gastric emptying and intestinal transit, but pretreatment of animals with SB204070 did not influence the effect of jatrorrhizine on gastric emptying and intestinal transit in postoperative ileus.

Conclusions Jatrorrhizine offset postoperative ileus-induced delayed gastric emptying and intestinal transit in rats, an action mediated via the cholinergic pathway, but not involving activation of 5-HT₄ receptors.

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Volume64, Issue3

March 2012

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Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus

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Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus

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