Antithrombotic and Antiplatelet Activities of Korean Red Ginseng Extract
Correction(s) for this article
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Erratum
- Volume 103Issue 6Basic & Clinical Pharmacology & Toxicology
- pages: 588-588
- First Published online: November 11, 2008
Yong-Ri Jin
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju,
Search for more papers by this authorJi Yeon Yu
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorJung-Jin Lee
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorSoon-Hyang You
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorJin-Ho Chung
College of Pharmacy, Seoul National University, Seoul,
Search for more papers by this authorJi-Yoon Noh
College of Pharmacy, Seoul National University, Seoul,
Search for more papers by this authorJi-Hyun Im
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorXiang-Hua Han
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorTack-Joong Kim
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorKyeong-Soeb Shin
College of Medicine, Chungbuk National University, Cheongju, and
Search for more papers by this authorJae Joon Wee
KT & G Central Research Institute, Daejeon, South Korea
Search for more papers by this authorYeo-Pyo Yun
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorYong-Ri Jin
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju,
Search for more papers by this authorJi Yeon Yu
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorJung-Jin Lee
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorSoon-Hyang You
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorJin-Ho Chung
College of Pharmacy, Seoul National University, Seoul,
Search for more papers by this authorJi-Yoon Noh
College of Pharmacy, Seoul National University, Seoul,
Search for more papers by this authorJi-Hyun Im
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorXiang-Hua Han
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorTack-Joong Kim
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorKyeong-Soeb Shin
College of Medicine, Chungbuk National University, Cheongju, and
Search for more papers by this authorJae Joon Wee
KT & G Central Research Institute, Daejeon, South Korea
Search for more papers by this authorYeo-Pyo Yun
College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju,
Search for more papers by this authorAbstract
Abstract: The antithrombotic and antiplatelet activities of Korean red ginseng extract (KRGE) were examined on rat carotid artery thrombosis in vivo and platelet aggregation in vitro and ex vivo. The KRGE significantly prevented rat carotid arterial thrombosis in vivo in a dose-dependent manner. Administration of the KRGE to rats significantly inhibited adenosine diphosphate (ADP)- and collagen-induced platelet aggregation ex vivo, although it failed to prolong coagulation times such as activated partial thromboplastin and prothrombin time indicating that the antithrombotic effect of the red ginseng may be due to its antiplatelet aggregation rather than anticoagulation effect. In line with the above observations, the red ginseng inhibited the U46619-, arachidonic acid-, collagen- and thrombin-induced rabbit platelet aggregations in vitro in a concentration-dependent manner, with IC50 values of 390 ± 15, 485 ± 19, 387 ± 11 and 335 ± 15 µg/ml, respectively. Consistently, serotonin secretion was also inhibited by ginseng in the same pattern. These results suggest that the red ginseng has a potent antithrombotic effect in vivo, which may be due to the antiplatelet rather than the anticoagulation activity, and the red ginseng intake may be beneficial for individuals with high risks of thrombotic and cardiovascular diseases.
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