The Association Between Endometriosis and Polymorphisms in the Interleukin-1 Family Genes in Korean Women
Sungwook Chun
Department of Obstetrics and Gynecology, College of Medicine, Inje University, Haeundae Paik Hospital, Busan, Korea
Search for more papers by this authorHoon Kim
Department of Obstetrics and Gynecology, Incheon Medical Center, Incheon, Korea
Search for more papers by this authorSeung-Yup Ku
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Clinical Research Institute, Seoul National University, Seoul, Korea
Search for more papers by this authorChang Suk Suh
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Clinical Research Institute, Seoul National University, Seoul, Korea
Search for more papers by this authorSeok Hyun Kim
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Clinical Research Institute, Seoul National University, Seoul, Korea
Search for more papers by this authorCorresponding Author
Jung Gu Kim
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Clinical Research Institute, Seoul National University, Seoul, Korea
Correspondence
Jung Gu Kim, Department of Obstetrics and Gynecology, Seoul National University Hospital, 28 Yeungun-dong, Chongno-Ku, Seoul 110-744, Korea.
E-mail: [email protected]
Search for more papers by this authorSungwook Chun
Department of Obstetrics and Gynecology, College of Medicine, Inje University, Haeundae Paik Hospital, Busan, Korea
Search for more papers by this authorHoon Kim
Department of Obstetrics and Gynecology, Incheon Medical Center, Incheon, Korea
Search for more papers by this authorSeung-Yup Ku
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Clinical Research Institute, Seoul National University, Seoul, Korea
Search for more papers by this authorChang Suk Suh
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Clinical Research Institute, Seoul National University, Seoul, Korea
Search for more papers by this authorSeok Hyun Kim
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Clinical Research Institute, Seoul National University, Seoul, Korea
Search for more papers by this authorCorresponding Author
Jung Gu Kim
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Clinical Research Institute, Seoul National University, Seoul, Korea
Correspondence
Jung Gu Kim, Department of Obstetrics and Gynecology, Seoul National University Hospital, 28 Yeungun-dong, Chongno-Ku, Seoul 110-744, Korea.
E-mail: [email protected]
Search for more papers by this authorAbstract
Problem
To investigate the association between polymorphisms of the interleukin-1 (IL-1) family genes and endometriosis in Korean women.
Method of study
In this case–control study, the IL-1α −889C>T, IL-1 receptor antagonist (IL-1RA) 86-bp microsatellite, IL-1 receptor 1 (IL-1R1) 52C>A, 294C>T, 1498T>C, 1632A>G, IL-1R2 rs2072472 C>T and rs7561460 C>T polymorphisms were analyzed in women with (n = 138) and without (n = 214) endometriosis using restriction fragment length polymorphism (RFLP) analysis, TaqMan assay, or DNA sequencing. Serum IL-1α, soluble IL-1RA (sIL-1RA), and sIL-1R2 levels were measured by enzyme-linked immunosorbent assay (ELISA).
Results
Among the polymorphisms measured, the 1498T>C polymorphisms in the IL-1R1 gene were found to be related with early-stage endometriosis but not with advanced-stage endometriosis. The genotypes with at least one T allele (CT + TT) were less frequently observed in early-stage endometriosis compared with normal controls (OR = 0.44, 95% CI = 0.22–0.87, P = 0.02). Serum sIL-1R2 levels were significantly lower (P < 0.01) in women with endometriosis than in normal controls, whereas no difference in serum sIL-1RA levels between these two groups was noted. The single and haplotype genotypes of the IL-1R2 and IL-1RA microsatellite polymorphisms were not related with these serum levels.
Conclusion
The IL-1R1 1498T>C polymorphism is associated with early-stage endometriosis in Korean women.
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