Volume 68, Issue 1 pp. 68-74
Original Article

Serum sTREM-1 (Soluble Triggering Receptor Expressed on Myeloid Cells-1) Associates Negatively with Embryo Quality in Infertility Patients

Kadri Haller-Kikkatalo

Corresponding Author

Kadri Haller-Kikkatalo

Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia

Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia

Women's Clinic, Tartu University Hospital, Tartu, Estonia

These authors contributed equally.

Correspondence

Kadri Haller-Kikkatalo, Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Ravila 19, Tartu 50411, Estonia.

E-mail: [email protected]

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Aili Sarapik

Aili Sarapik

Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia

These authors contributed equally.Search for more papers by this author
Gilbert C. Faure

Gilbert C. Faure

Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France

CHU Nancy-Brabois, Vandoeuvre, France

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Marie-Christine Béné

Marie-Christine Béné

Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France

CHU Nancy-Brabois, Vandoeuvre, France

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Frédéric Massin

Frédéric Massin

Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France

CHU Nancy-Brabois, Vandoeuvre, France

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Andres Salumets

Andres Salumets

Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia

Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia

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Raivo Uibo

Raivo Uibo

Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia

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First published: 09 January 2012
Citations: 3

Abstract

Problem

Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a useful biomarker of infection and inflammation.

Method of study

We studied serum and follicular fluid sTREM-1 in infertile patients (N = 110) utilizing enzyme-linked immunosorbent assay.

Results

Serum and follicular sTREM-1 were in good correlation (Pearson's correlation 0.56, P < 0.0001) with higher values in follicular fluid (140.4 ± 34.4 and 115.6 ± 35.1 pg/mL, t-test, P < 0.0001). Endometriosis associated with lower follicular and serum sTREM-1 compared with male factor infertility patients (age-adjusted r = −25.7 pg/mL, P = 0.018; r = −22.1 pg/mL, P = 0.030). No associations between follicular or serum sTREM-1 and clinical parameters were found, except higher serum sTREM-1 associated with lower embryo quality in all patients (adjusted r = −0.3%, P = 0.033), with a cutoff value between 111.5 and 113.3 pg/mL (OR = 0.38, P = 0.048; OR = 0.34, P = 0.028) predicting that more than 39% of embryos would be with good quality.

Conclusion

Serum sTREM-1 could represent a prognostic marker for female fecundity, probably indicating impaired inflammatory reaction of immune system.

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