Serum sTREM-1 (Soluble Triggering Receptor Expressed on Myeloid Cells-1) Associates Negatively with Embryo Quality in Infertility Patients
Corresponding Author
Kadri Haller-Kikkatalo
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
Women's Clinic, Tartu University Hospital, Tartu, Estonia
These authors contributed equally.Correspondence
Kadri Haller-Kikkatalo, Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Ravila 19, Tartu 50411, Estonia.
E-mail: [email protected]
Search for more papers by this authorAili Sarapik
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
These authors contributed equally.Search for more papers by this authorGilbert C. Faure
Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
CHU Nancy-Brabois, Vandoeuvre, France
Search for more papers by this authorMarie-Christine Béné
Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
CHU Nancy-Brabois, Vandoeuvre, France
Search for more papers by this authorFrédéric Massin
Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
CHU Nancy-Brabois, Vandoeuvre, France
Search for more papers by this authorAndres Salumets
Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
Search for more papers by this authorRaivo Uibo
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
Search for more papers by this authorCorresponding Author
Kadri Haller-Kikkatalo
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
Women's Clinic, Tartu University Hospital, Tartu, Estonia
These authors contributed equally.Correspondence
Kadri Haller-Kikkatalo, Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Ravila 19, Tartu 50411, Estonia.
E-mail: [email protected]
Search for more papers by this authorAili Sarapik
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
These authors contributed equally.Search for more papers by this authorGilbert C. Faure
Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
CHU Nancy-Brabois, Vandoeuvre, France
Search for more papers by this authorMarie-Christine Béné
Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
CHU Nancy-Brabois, Vandoeuvre, France
Search for more papers by this authorFrédéric Massin
Laboratoire d'Immunologie, Université Henri Poincaré, Vandoeuvre lès Nancy, France
CHU Nancy-Brabois, Vandoeuvre, France
Search for more papers by this authorAndres Salumets
Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia
Search for more papers by this authorRaivo Uibo
Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia
Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
Search for more papers by this authorAbstract
Problem
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a useful biomarker of infection and inflammation.
Method of study
We studied serum and follicular fluid sTREM-1 in infertile patients (N = 110) utilizing enzyme-linked immunosorbent assay.
Results
Serum and follicular sTREM-1 were in good correlation (Pearson's correlation 0.56, P < 0.0001) with higher values in follicular fluid (140.4 ± 34.4 and 115.6 ± 35.1 pg/mL, t-test, P < 0.0001). Endometriosis associated with lower follicular and serum sTREM-1 compared with male factor infertility patients (age-adjusted r = −25.7 pg/mL, P = 0.018; r = −22.1 pg/mL, P = 0.030). No associations between follicular or serum sTREM-1 and clinical parameters were found, except higher serum sTREM-1 associated with lower embryo quality in all patients (adjusted r = −0.3%, P = 0.033), with a cutoff value between 111.5 and 113.3 pg/mL (OR = 0.38, P = 0.048; OR = 0.34, P = 0.028) predicting that more than 39% of embryos would be with good quality.
Conclusion
Serum sTREM-1 could represent a prognostic marker for female fecundity, probably indicating impaired inflammatory reaction of immune system.
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