Effect of physical activity and muscle morphology on endothelial function and arterial stiffness
M. Rönnback
Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland,
Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland,
Search for more papers by this authorM. Hernelahti
Unit for Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland,
Search for more papers by this authorE. Hämäläinen
Department of Clinical Chemistry, Helsinki University Central Hospital, Laboratory of Women's Hospital, Helsinki, Finland
Search for more papers by this authorP. H. Groop
Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland,
Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland,
Search for more papers by this authorH. Tikkanen
Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland,
Unit for Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland,
Search for more papers by this authorM. Rönnback
Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland,
Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland,
Search for more papers by this authorM. Hernelahti
Unit for Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland,
Search for more papers by this authorE. Hämäläinen
Department of Clinical Chemistry, Helsinki University Central Hospital, Laboratory of Women's Hospital, Helsinki, Finland
Search for more papers by this authorP. H. Groop
Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland,
Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland,
Search for more papers by this authorH. Tikkanen
Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland,
Unit for Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland,
Search for more papers by this authorAbstract
Physically active persons have a reduced risk of atherosclerotic disease. Arterial stiffness and endothelial dysfunction are important risk factors for cardiovascular disease. A high proportion of type I (slow-twitch) muscle fibers in skeletal muscle is associated with a favorable cardiovascular risk profile. We tested physical activity and muscle fiber-type distribution as determinants of endothelial function and arterial stiffness in middle-aged men. Fifty-four men (median age 58) who underwent a muscle biopsy in 1984 were re-studied in 2003. Aortic pulse wave velocity (PWV) and pulse wave reflection were assessed by applanation tonometry. Endothelial function was tested by examining the effects of salbutamol and nitroglycerin on pulse wave reflection. In multiple regression analyses aortic PWV (R2=0.51) correlated positively with age (P=0.017), BMI (P=0.001), and systolic blood pressure (P=0.004). A high augmentation index (R2=0.33) was associated with smoking (P<0.001), high LDL cholesterol (P=0.02), and elevated diastolic blood pressure (P=0.03). Impaired endothelial function (R2=0.37) was associated with high age (P=0.04), high LDL cholesterol (P=0.017), high triglycerides (P=0.027), and high physical activity (P=0.005). Muscle fiber-type distribution is not a determinant of arterial stiffness or endothelial function. Impaired endothelial function was observed in physically active men, underlining the need for further research.
References
- Bergholm R, Mäkimattila S, Valkonen M, Liu ML, Lahdenperä S, Taskinen MR, Sovijärvi A, Malmberg P, Yki-Järvinen H. Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilatation in vivo. Atherosclerosis 1999: 145: 341–349.
- Bertovic DA, Waddell TK, Gatzka CD, Cameron JD, Dart AM, Kingwell BA. Muscular strength training is associated with low arterial compliance and high pulse pressure. Hypertension 1999: 33: 1385–1391.
- Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, Laurent S. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients. Hypertension 2002: 39: 10–15.
- Brownell KD, Bachorik PS. Changes in plasma lipids and lipoprotein levels in men and women after a program of moderate exercise. Circulation 1982: 65: 477–484.
- Dart A, Silagy C, Dewar E, Jennings G, McNeil J. Aortic distensibility and left ventricular structure and function in isolated systolic hypertension. Eur Heart J 1993: 14: 1465–1470.
- Hedman A, Reneland R, Lithell HO. Alterations in skeletal muscle morphology in glucose tolerant elderly hypertensive men: relationship to development of hypertension and heart rate. J Hypertens 2000: 18: 559–565.
- Hernelahti M, Tikkanen HO, Karjalainen J, Kujala UM. Muscle fiber-type distribution as a predictor of blood pressure. A 19-year follow-up study. Hypertension 2005: 45: 1019–1023.
- Juhlin-Dannfelt A, Frisk-Holmberg M, Karlsson J, Tesch P. Central and peripheral circulation relation to muscle fiber composition in normal and hypertensive men. Clin Sci 1979: 56: 335–340.
- Kool MJ, Hoeks AP, Struijker Boudier HA, Reneman RS, Van Bortel LM. Short- and long-term effects of smoking on arterial wall properties in habitual smokers. J Am Coll Cardiol 1993: 22: 1881–1886.
- Kujala UM, Marti P, Kaprio J, Hernelahti M, Tikkanen H, Sarna S. Occurrence of chronic disease in former top-level athletes. Predominance of benefits, risks or selection effects? Sports Med 2003: 33: 553–561.
- Lakka T, Salonen JT. Intra-person variability of various physical activity assessments in the Kuopio ischaemic heart disease risk factor study. Int J Epidemiol 1992a: 21: 467–472.
- Lakka T, Salonen JT. Physical activity and serum lipids: a cross-sectional population study in eastern Finnish men. Am J Epidemiol 1992b: 136: 806–818.
- Lakka T, Salonen JT. The physical activity questionnaires of the Kuopio Ischemic Heart Disease Study (KIHD). Med Sci Sports Exerc 1997: 29 (Suppl. 6): S46–S58.
- Mackey RH, Sutton-Tyrrell K, Vaitkevicius PV, Sakkinen PA, Lyles MF, Spurgeon HA, Lakatta EG, Kuller LH. Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study. Am J Hypertens 2002: 15 (1 Part 1): 16–23.
- Moyna NM, Thompson PD. The effect of physical activity on endothelial function in man. Acta Physiol Scand 2004: 180: 113–123.
- O'Rourke MF, Gallagher DE. Pulse wave analysis. J Hypertension 1996: 14 (Suppl. 5): 147–157.
- Paffenbarger RS Jr, Jung DL, Leung RW, Hyde RT. Physical activity and hypertension: an epidemiological view. Ann Med 1991: 23: 319–327.
- Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990: 323: 22–27.
- Rinder MR, Spina RJ, Ehsani AA. Enhanced endothelium-dependent vasodilation in older endurance-trained men. J Appl Physiol 2000: 88: 761–766.
- Salonen JT, Lakka T. Assessment of physical activity in population studies – validity and consistency of the methods in the Kuopio ischemic heart disease risk factor study. Scand J Sports Sci 1987: 9: 89–95.
- Schmidt-Trucksass AS, Grathwohl D, Frey I, Schmid A, Boragk R, Upmeier C, Keul J, Huonker M. Relation of leisure-time physical activity to structural and functional arterial properties of the common carotid artery in male subjects. Atherosclerosis 1999: 145: 107–114.
- Schmitz KH, Arnett DK, Bank A, Liao D, Evans GW, Evenson KR, Stevens J, Sorlie P, Folsom AR. Arterial distensibility and physical activity in the ARIC study. Med Sci Sports Exerc 2001: 33: 2065–2071.
- Simoneau J-A, Bouchard C. Genetic determinism of fibre type proportion in human skeletal muscle. FASEB J 1995: 9: 1091–1095.
- Spangenburg EE, Booth FW. Molecular regulation of individual skeletal muscle fibre types. Acta Physiol Scand 2003: 178: 413–424.
- Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Salvetti A. Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 2000: 101: 2896–2901.
- Tanaka H, DeSouza CA, Seals DR. Absence of age-related increase in central arterial stiffness in physically active women. ATVB 1998: 18: 127–132.
- Tikkanen HO, Hämäläinen E, Härkönen M. Significance of skeletal muscle properties on fitness, long-term physical training and serum lipids. Atherosclerosis 1999: 142: 367–378.
- Tikkanen HO, Hämäläinen E, Sarna S, Adlercreutz H, Harkonen M. Associations between skeletal muscle properties, physical fitness, physical activity and coronary heart disease risk factors in men. Atherosclerosis 1998: 137: 377–389.
- Wade AJ, Marbut MM, Round JM. Muscle fibre type and aetiology of obesity. Lancet 1990: 335: 805–808.
- Wildman RP, Mackey RH, Bostom A, Thompson T, Sutton-Tyrrell K. Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension 2003: 42: 468–473.
- Wilkinson IB, Fuchs SA, Jansen IM, Spratt JC, Murray GD, Cockcroft JR, Webb DJ. The reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis. J Hypertens 1998: 16: 2079–2084.
- Wilkinson IB, Hall IR, MacCallum H, Mackenzie IS, McEniery CM, Van Der Arend BJ, Shu YE, Mackay LS, Webb DJ, Cockcroft JR. Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function. Arterioscler Thromb Vasc Biol 2002a: 22: 147–152.
- Wilkinson IB, MacCallum H, Flint L, Cockcroft JR, Newby DE, Webb DJ. The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiology 2000: 525: 263–270.
- Wilkinson IB, Prasad K, Hall IR, Thomas A, MacCallum H, Webb DJ, Frenneaux MP, Cockcroft JR. Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol 2002b: 39: 1005–1011.
