Oral and Genital Human Herpesvirus 8 and Human Papillomavirus in heterosexual partners
Catarina da Mota Vasconcelos Brasil,
Camila Maria Beder Ribeiro,
Jair Carneiro Leão,
Catarina da Mota Vasconcelos Brasil
Departmento de Clínica e Odontologia Preventiva, School of Dentistry, Oral Medicine Unit, Universidade Federal de Pernambuco/UFPE, Recife, PE, Brazil
Search for more papers by this authorCamila Maria Beder Ribeiro
Centro Universitario CESMAC- Maceio, AL, Brazil
Search for more papers by this authorJair Carneiro Leão
Departmento de Clínica e Odontologia Preventiva, School of Dentistry, Oral Medicine Unit, Universidade Federal de Pernambuco/UFPE, Recife, PE, Brazil
Search for more papers by this authorCatarina da Mota Vasconcelos Brasil,
Camila Maria Beder Ribeiro,
Jair Carneiro Leão,
Catarina da Mota Vasconcelos Brasil
Departmento de Clínica e Odontologia Preventiva, School of Dentistry, Oral Medicine Unit, Universidade Federal de Pernambuco/UFPE, Recife, PE, Brazil
Search for more papers by this authorCamila Maria Beder Ribeiro
Centro Universitario CESMAC- Maceio, AL, Brazil
Search for more papers by this authorJair Carneiro Leão
Departmento de Clínica e Odontologia Preventiva, School of Dentistry, Oral Medicine Unit, Universidade Federal de Pernambuco/UFPE, Recife, PE, Brazil
Search for more papers by this authorProf. Jair Carneiro Leão, PhD, Av. Prof. Moraes Rego, 1235, Recife PE - CEP 50670-901, Brazil. Tel: +55 81 21268818, Fax: +55 81 21268818, E-mail: [email protected]
Abstract
Background: The purpose of this study was to verify a possible co-infection of human herpesvirus 8 (HHV-8) in commonly associated human papillomavirus (HPV) penile lesions and to determine the frequency of detection of these viruses in the oral mucosa of their female counterparts.
Methods: Thirty-one male subjects underwent penile swabs from clinical HPV-related lesions. Their female counterparts underwent swabs of the vagina, uterine cervix, and oral mucosa. HPV and HHV-8 detection was performed by polymerase chain reaction using the consensus primers MY11/MY09 and KS1/KS2, respectively.
Results: HPV DNA was detected in 31/31 penile lesions. HPV DNA was also detected in 18/31 (58%) female genital brushings and 17/31 (54%) female oral brushings. HHV-8 DNA was detected in 1/31 (3.2%) male genital brushings and 3/31 (9.6%) female oral mucosa brushings. None of the female genital brushings were HHV-8 DNA-infected.
Conclusions: Based upon the results of this study, co-infection between HPV and HHV-8 in malignant and pre-malignant penile lesions is an unlikely finding.
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