Volume 40, Issue 9 pp. 721-725

Cell apoptosis and proliferation in salivary glands of Sjögren’s syndrome

B. Busamia,

B. Busamia

Physiology Department, School of Dentistry, Córdoba National University, Córdoba, Argentina

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M. A. Gonzalez-Moles,

M. A. Gonzalez-Moles

Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain

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I. Ruiz-Avila,

I. Ruiz-Avila

Pathology Department, “Complejo Hospitalario”, Jaen, Spain

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M. Brunotto,

M. Brunotto

Physiology Department, School of Dentistry, Córdoba National University, Córdoba, Argentina

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J. A. Gil-Montoya,

J. A. Gil-Montoya

Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain

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M. Bravo,

M. Bravo

Preventive and Public Health in Dentistry Department, School of Dentistry, University of Granada, Granada, Spain

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C. Gobbi,

C. Gobbi

Sanatorio Allende, Córdoba, Argentina

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A. Finkelberg,

A. Finkelberg

Physiology Department, School of Dentistry, Córdoba National University, Córdoba, Argentina

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B. Busamia,

B. Busamia

Physiology Department, School of Dentistry, Córdoba National University, Córdoba, Argentina

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M. A. Gonzalez-Moles,

M. A. Gonzalez-Moles

Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain

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I. Ruiz-Avila,

I. Ruiz-Avila

Pathology Department, “Complejo Hospitalario”, Jaen, Spain

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M. Brunotto,

M. Brunotto

Physiology Department, School of Dentistry, Córdoba National University, Córdoba, Argentina

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J. A. Gil-Montoya,

J. A. Gil-Montoya

Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain

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M. Bravo,

M. Bravo

Preventive and Public Health in Dentistry Department, School of Dentistry, University of Granada, Granada, Spain

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C. Gobbi,

C. Gobbi

Sanatorio Allende, Córdoba, Argentina

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A. Finkelberg,

A. Finkelberg

Physiology Department, School of Dentistry, Córdoba National University, Córdoba, Argentina

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First published: 26 April 2011

https://doi.org/10.1111/j.1600-0714.2011.01042.x

Citations: 8

Dr. Beatriz Busamia, Departamento Biología Bucal, Facultad Odontología-Universidad Nacional de Córdoba, Pabellón Argentina-Haya de la Torre s/n, Ciudad Universitaria-CP5000 Córdoba, Argentina. Tel: 54-351-4333032, Fax: 54-351-433-4179, E-mail: [email protected]

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Abstract

J Oral Pathol Med (2011) 40: 721–725

Background: Sjögren’s syndrome (SS) occurs associated with parotid neoplasm, non-Hodgkin’s B-cell lymphoma, which could impair the condition or be life-threatening for patients. The aim of this work was to analyze cell proliferation and apoptosis modifications in acinar, ductal and inflammatory infiltrate in salivary glands (SG) in patients with Sjögren Syndrome, keratoconjunctivitis, or stomatitis sicca or in healthy subjects, to establish parameters that indicate the likelihood of malignancy of the disease in populations at risk.

Methods: A study was performed with n = 58 histological samples of lower lip SG from patients diagnosed with SS, keratoconjunctivitis, or stomatitis sicca (SICCA) and from healthy subjects (C). Ki67 and caspase-3 immunolabeling were performed.

Results: The most important result was significant differences between the three study groups in Ki67 and caspase-3 markers (P < 0.0001) in infiltrated lymphocytes.

Conclusion: The results of this work are indicative of a high degree of proliferation (85%) in infiltrated lymphocytes (IL) associated with SS which, according the literature, could be considered a risk. Furthermore, the markers used in this work are widely known and represent a lower cost than others and can be used to determine risk groups within the population of SS patients, enabling their follow-up.

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Volume40, Issue9

October 2011

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Cell apoptosis and proliferation in salivary glands of Sjögren’s syndrome

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Cell apoptosis and proliferation in salivary glands of Sjögren’s syndrome

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