Volume 18, Issue 1 pp. 34-39

Influence of cyclosporin A on quality of bone around integrated dental implants: a radiographic study in rabbits

Celso Eduardo Sakakura

Celso Eduardo Sakakura

Department of Oral Diagnosis and Surgery, School of Dentistry, State University of São Paulo, UNESP, Araraquara, SP, Brazil

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Elcio Marcantonio Jr

Elcio Marcantonio Jr

Department of Oral Diagnosis and Surgery, School of Dentistry, State University of São Paulo, UNESP, Araraquara, SP, Brazil

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Ann Wenzel

Ann Wenzel

Department of Oral Radiology, School of Dentistry, Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark

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Gulnara Scaf

Gulnara Scaf

Department of Oral Diagnosis and Surgery, School of Dentistry, State University of São Paulo, UNESP, Araraquara, SP, Brazil

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First published: 05 December 2006
Citations: 35
Correspondence to:
Gulnara Scaf
Departamento de Diagnóstico e Cirurgia
Faculdade de Odontologia de Araraquara
UNESP, Rua Humaitá 1680, 14801-903
Araraquara, SP
Brazil
Tel.: +55 (16) 3322 3285
Fax: +55 (16) 3301 6369
e-mail: [email protected]

Abstract

Objectives: To evaluate the influence of cyclosporin A (CsA) administration on bone around integrated dental implants assessed by a bone quality index and by quantitative subtraction radiography.

Material and methods: A total of 36 machine surface commercial implants were placed in 18 adult rabbits. After a 3-month healing period without any disturbance, the animals were randomly divided into three groups of six animals each. Group A was sacrificed at this time. CsA was injected subcutaneously in an immunosuppressive dose of 10 mg/kg/day in a test group (Group T), and a Group B served as a control, receiving only vehicle. After 3 months of cyclosporin administration, the animals of both Groups B and T were sacrificed. Radiographs were obtained at implant surgery and at the day of sacrifice with a CMOS sensor. Bone quality around the implants was compared between the groups using a bone quality index and quantitative subtraction radiography.

Results: The bone analysis showed that in Group T, the bone quality changed dramatically from a dense cortical to a loose trabecular bone structure (P<0.0001, χ2 test) while in Groups A and B there were no significant differences. Quantitative digital subtraction radiography showed significantly (P<0.05) lower gray shade values (radiographic density) in a region of bone formation around the implants in Group T (118±12) than in Groups A (161±6) and B (186±10).

Conclusion: Within the limits of this study, CsA administration has a negative effect on the quality of bone around integrated dental implant.

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