Investigating Agenesis of the Corpus Callosum Using Functional MRI: A Study Examining Interhemispheric Coordination of Motor Control
Cheemun Lum MD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorMary Pat McAndrews PhD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorAndrei I. Holodny MD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorKathleen A. McManus BA
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorAdrian Crawley PhD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorSantanu Chakraborty DMRD, FRCD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorDavid J. Mikulis MD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorCheemun Lum MD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorMary Pat McAndrews PhD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorAndrei I. Holodny MD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorKathleen A. McManus BA
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorAdrian Crawley PhD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorSantanu Chakraborty DMRD, FRCD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorDavid J. Mikulis MD
From the Department of Diagnostic Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Canada (CL, SC); Department of Psychology, University of Toronto, Toronto, Canada (MPM); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (AIH, KAM); and Department of Medical Imaging, Toronto Western Hospital, University of Toronto, Toronto, Canada (AC, DJM).
Search for more papers by this authorJ Neuroimaging 2011;21:65-68.
ABSTRACT
We report fMRI findings in 3 asymptomatic cases of agenesis of the corpus callosum, the largest white matter bundle in the brain, which is responsible for interhemispheric transfer of information. Sensory information was presented to 1 hemisphere, and the patients had to generate a motor response governed by the contralateral hemisphere. Enhanced ipsilateral motor pathways have been suggested as a compensation method for people with agenesis of the corpus callosums; our functional magnetic resonance imaging data did not support this theory.
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