Volume 21, Issue 2 pp. 132-137

Evaluation of the Effects of Thyrotropin Releasing Hormone (TRH) Therapy on Regional Cerebral Blood Flow in the Cerebellar Variant of Multiple System Atrophy Using 3DSRT

Noriyuki Kimura PhD,

Noriyuki Kimura PhD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Toshihide Kumamoto MD,

Toshihide Kumamoto MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Teruaki Masuda MD,

Teruaki Masuda MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Yuki Nomura MD,

Yuki Nomura MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Takuya Hanaoka MD,

Takuya Hanaoka MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Yusuke Hazama MD,

Yusuke Hazama MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Toshio Okazaki MD,

Toshio Okazaki MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Noriyuki Kimura PhD,

Noriyuki Kimura PhD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Toshihide Kumamoto MD,

Toshihide Kumamoto MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Teruaki Masuda MD,

Teruaki Masuda MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Yuki Nomura MD,

Yuki Nomura MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Takuya Hanaoka MD,

Takuya Hanaoka MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Yusuke Hazama MD,

Yusuke Hazama MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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Toshio Okazaki MD,

Toshio Okazaki MD

From the Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan

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First published: 24 March 2011

https://doi.org/10.1111/j.1552-6569.2009.00411.x

Citations: 16

Correspondence: Address correspondence to Noriyuki Kimura, PhD, Department of Internal Medicine III, Oita University, Faculty of Medicine, Idaigaoka 1-1, Hasama, Yufu, Oita 879-5593, Japan. E-mail: [email protected]

J Neuroimaging 2011;21:132-137.

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Abstract

ABSTRACT

BACKGROUND

Thyrotropin releasing hormone (TRH) improves cerebellar ataxia and cerebellar perfusion in patients with spinocerebellar degeneration. It is not known whether TRH therapy can improve the cerebellar regional cerebral blood flow (rCBF) or not in patients with cerebellar variant of multiple-system atrophy (MSA-C).

PATIENTS AND METHODS

Seven patients with MSA-C received TRH intravenously (2 mg/day) for 14 days. Clinical efficacy was assessed using the International Cooperative Ataxia Rating Scale (ICARS) and brain perfusion single photon emission-computed tomography was performed before and after therapy. The rCBF in each region of interest (ROI) was calculated using 3DSRT, a fully automated the ROI technique.

RESULTS

The ICARS scores slightly improved in 6 of the 7 patients after TRH therapy, but this was not statistically significant. After TRH therapy, the cerebellar rCBF reduced in the 6 of 7 patients and the mean rCBF in cerebellum also significantly decreased (P= 0.029, paired t-test), whereas the rCBF in the precentral segment tend to increase (P= 0.048, paired t-test).

CONCLUSION

TRH therapy may be less effective on cerebellar ataxia and cerebellar rCBF in MSA-C. The 3DSRT program may be useful for the evaluation of the efficacy of TRH therapy on cerebral blood flow.

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Citing Literature

Volume21, Issue2

April 2011

Pages 132-137

Evaluation of the Effects of Thyrotropin Releasing Hormone (TRH) Therapy on Regional Cerebral Blood Flow in the Cerebellar Variant of Multiple System Atrophy Using 3DSRT

Abstract

ABSTRACT

BACKGROUND

PATIENTS AND METHODS

RESULTS

CONCLUSION

References

Citing Literature

References

Information

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Evaluation of the Effects of Thyrotropin Releasing Hormone (TRH) Therapy on Regional Cerebral Blood Flow in the Cerebellar Variant of Multiple System Atrophy Using 3DSRT

Abstract

ABSTRACT

BACKGROUND

PATIENTS AND METHODS

RESULTS

CONCLUSION

References

Citing Literature

References

Related

Information