A Prospective Randomized Study to Assess the Efficacy of Rate and Site of Atrial Pacing on Long-Term Development of Atrial Fibrillation
CHU-PAK LAU M.D.,
CHUN-CHIEH WANG M.D.,
TACHAPONG NGARMUKOS M.D.,
YOU-HO KIM M.D., CHI-WOON KONG M.D., RAZALI OMAR M.D., CHARN SRIRATANASATHAVORN M.D.,
MUHAMMAD MUNAWAR M.D., RUTH KAM M.D., KATHY LF LEE M.D.,
ELIZABETH OI-YAN LAU Ph.D., HUNG-FAT TSE M.D., Ph.D.,
SAFE Study Steering Committee for the SAFE Study Group,
CHU-PAK LAU M.D.
Queen Mary Hospital, University of Hong Kong, Hong Kong
Search for more papers by this authorCHUN-CHIEH WANG M.D.
Chang Gung Memorial Hospital, Linkou, Taiwan
Search for more papers by this authorTACHAPONG NGARMUKOS M.D.
Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Search for more papers by this authorCHARN SRIRATANASATHAVORN M.D.
Siriraj Hospital, Mahidol University, Bangkok, Thailand
Search for more papers by this authorKATHY LF LEE M.D.
Queen Mary Hospital, University of Hong Kong, Hong Kong
Search for more papers by this authorHUNG-FAT TSE M.D., Ph.D.
Queen Mary Hospital, University of Hong Kong, Hong Kong
Search for more papers by this authorSAFE Study Steering Committee for the SAFE Study Group
The complete SAFE Study Group is listed in the Appendix 1.
Search for more papers by this authorCHU-PAK LAU M.D.,
CHUN-CHIEH WANG M.D.,
TACHAPONG NGARMUKOS M.D.,
YOU-HO KIM M.D., CHI-WOON KONG M.D., RAZALI OMAR M.D., CHARN SRIRATANASATHAVORN M.D.,
MUHAMMAD MUNAWAR M.D., RUTH KAM M.D., KATHY LF LEE M.D.,
ELIZABETH OI-YAN LAU Ph.D., HUNG-FAT TSE M.D., Ph.D.,
SAFE Study Steering Committee for the SAFE Study Group,
CHU-PAK LAU M.D.
Queen Mary Hospital, University of Hong Kong, Hong Kong
Search for more papers by this authorCHUN-CHIEH WANG M.D.
Chang Gung Memorial Hospital, Linkou, Taiwan
Search for more papers by this authorTACHAPONG NGARMUKOS M.D.
Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Search for more papers by this authorCHARN SRIRATANASATHAVORN M.D.
Siriraj Hospital, Mahidol University, Bangkok, Thailand
Search for more papers by this authorKATHY LF LEE M.D.
Queen Mary Hospital, University of Hong Kong, Hong Kong
Search for more papers by this authorHUNG-FAT TSE M.D., Ph.D.
Queen Mary Hospital, University of Hong Kong, Hong Kong
Search for more papers by this authorSAFE Study Steering Committee for the SAFE Study Group
The complete SAFE Study Group is listed in the Appendix 1.
Search for more papers by this authorAddress for correspondence: Professor C.P. Lau, Director, Institute of Cardiovascular Science and Medicine, Honorary Professor in Medicine, Division of Cardiology, Department of Medicine, Room 1927, 19/F, Block K, Queen Mary Hospital, Pokfulam Road, Hong Kong. Fax: 852-2818-6304; E-mail: [email protected]
This study is supported by St. Jude Medical Inc.
Dr. Lau received funds to support the core lab; he also received travel support to an investigators’ meeting and holding shares of common stock in an unspecified company relevant to this topic. Dr. Wang served as a member of the steering committee of the SAFE study. Dr. Ngarmukos received financial support for travel to an investigators’ meeting. Drs. Kong and Omar served on the advisory board of the SAFE study. Dr. Kam received travel support from Medtronic International to present poster at a meeting and also served on the clinical advisory boards of St. Jude Medical and Medtronic International Inc.
Abstract
The Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study is a single-blinded, parallel randomized designed multicenter study in pacemaker indicated patients with paroxysmal atrial fibrillation (AF). The objective is to evaluate whether the site of atrial pacing–-conventional right atrial appendage versus low atrial septal—with or without atrial overdrive pacing will influence the development of persistent AF. The study will provide a definitive answer to whether a different atrial pacing site or the use of AF suppression pacing or both can give incremental antiarrhythmic benefit when one is implanting a device for a patient with a history of paroxysmal AF.
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