Evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell (RBC) additive solutions on in vitro RBC measures
Pieter F. van der Meer
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorJose A. Cancelas
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorRebecca Cardigan
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorDana V. Devine
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorHans Gulliksson
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorRosemary L. Sparrow
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorRalph R. Vassallo
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorJanny de Wildt-Eggen
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorBärbel Baumann-Baretti
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorJohn R. Hess
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorfor the BEST Collaborative
Search for more papers by this authorPieter F. van der Meer
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorJose A. Cancelas
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorRebecca Cardigan
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorDana V. Devine
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorHans Gulliksson
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorRosemary L. Sparrow
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorRalph R. Vassallo
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorJanny de Wildt-Eggen
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorBärbel Baumann-Baretti
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorJohn R. Hess
From the Sanquin Blood Bank North West Region, Amsterdam, the Netherlands; the Hoxworth Blood Center, Cincinnati, Ohio; the National Health Service Blood & Transplant, Brentwood, UK; the Canadian Blood Services, Vancouver, British Columbia, Canada; the Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; the Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia; the American Red Cross, Philadelphia, Pennsylvania; the Sanquin Blood Bank North East Region, Groningen, the Netherlands, Haema AG, Berlin, Germany; and the University of Maryland, Blood Bank, Baltimore, Maryland.
Search for more papers by this authorfor the BEST Collaborative
Search for more papers by this authorAbstract
BACKGROUND: Whole blood (WB) can be held at room temperature (18-25°C) up to 8 hours after collection; thereafter the unit must be refrigerated, rendering it unsuitable for platelet (PLT) production. Overnight hold at room temperature before processing has logistic advantages, and we evaluated this process in an international multicenter study for both buffy coat (BC)- and PLT-rich plasma (PRP)-based blood components and compared three red blood cell (RBC) additive solutions (ASs) for their ability to offset effects of overnight hold.
STUDY DESIGN AND METHODS: Nine centers participated; seven used the BC method, and two used the PRP method. Four WB units were pooled and split; 1 unit was processed less than 8 hours from collection (Group A), and the other three (Groups B, C, and D) were held at room temperature and processed after 24 to 26 hours. RBCs in Groups A and B were resuspended in saline-adenine-glucose-mannitol, Group C in phosphate-adenine-guanosine-glucose-saline-mannitol, and Group D in ErythroSol-4 RBCs were stored at 2 to 6°C for 49 days.
RESULTS: RBCs from overnight-held WB had lower 2,3-diphosphoglycerate (2,3-DPG) and higher adenosine triphosphate (ATP). At the end of storage there were no differences between groups, apart from a slightly higher hemolysis in Group B. ErythroSol-4 showed a slightly higher initial ATP and 2,3-DPG content, but at the end of storage no differences were found.
CONCLUSION: Overnight hold of WB before processing has no lasting deleterious effects on in vitro quality of subsequently prepared components. The use of different RBC ASs did not appear to offer significant advantages in terms of RBC quality at the end, regardless of the processing method.
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