Transfusion of platelet components prepared with photochemical pathogen inactivation treatment during a Chikungunya virus epidemic in Ile de La Réunion
Patrice Rasonglès
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorMarie France Angelini-Tibert
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorPhilip Simon
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorCaroline Currie
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorHerve Isola
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorDaniel Kientz
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorMarc Slaedts
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorMichele Jacquet
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorDavid Sundin
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorLily Lin
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorLaurence Corash
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorJean Pierre Cazenave
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorPatrice Rasonglès
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorMarie France Angelini-Tibert
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorPhilip Simon
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorCaroline Currie
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorHerve Isola
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorDaniel Kientz
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorMarc Slaedts
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorMichele Jacquet
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorDavid Sundin
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorLily Lin
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorLaurence Corash
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorJean Pierre Cazenave
From the EFS Ile de La Réunion and CHR Centre Hospitalier Départemental Felix Guyon, St Denis, Ile de La Réunion, France; CHR Groupe Hospitalier Sud Réunion de St Pierre, Ile de La Réunion, France; Cerus Corporation, Concord, California; EFS Alsace, Strasbourg, France; Cerus Europe BV, Amersfoort, The Netherlands; the University of California School of Medicine, San Francisco, California; INSERM U.311 and Université Louis Pasteur, Strasbourg, France.
Search for more papers by this authorThis study was supported in part by Cerus Corporation.
Abstract
BACKGROUND: During the Chikungunya virus (CHIKV) epidemic on Ile de La Réunion, France, more than 30% of 750,000 inhabitants were infected. Local blood donation was suspended to prevent transfusion-transmitted infection (TT-CHIKV). To sustain the availability of platelet (PLT) components, the Établissement Français du Sang implemented universal pathogen inactivation (INTERCEPT, Cerus Europe BV) of PLT components (CPAs). The study assessed the safety of PLT components treated with pathogen inactivation transfused in routine clinical practice.
STUDY DESIGN AND METHODS: This was a retrospective observational study using patient medical records and the AFSSAPS hemovigilance database (eFIT) to identify TT-CHIKV and adverse events (AEs) classified as acute transfusion reactions (ATRs) to PLT components prepared with pathogen inactivation.
RESULTS: During 1 year, 1950 INTERCEPT-CPAs were transfused to 335 adult, 51 pediatric, and 41 infant patients. Nineteen AEs were observed in 15 patients and 10 were classified as ATRs. Eight ATRs occurred in 6 pediatric hematology-oncology patients. No ATRs were observed in infants. The most frequently reported signs and symptoms were Grade 1 urticaria, itching, chills, fever, and anxiety. No cases of transfusion-related acute lung injury, TT-sepsis, or TT-CHIKV were detected.
CONCLUSIONS: INTERCEPT-CPAs were well tolerated in a broad range of patients, including infants. ATR incidence was low and when present ATRs were of mild severity.
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