Hemodynamic and Metabolic Changes During Exercise in Calves With Total Artificial Hearts of Different Sizes yet Similar Output
Keiji Kamohara
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorStephan Weber
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorRyan S. Klatte
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorViviane Luangphakdy
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorChristine R. Flick
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorYoshio Ootaki
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorMasatoshi Akiyama
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorFaruk Cingoz
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorChiyo Ootaki
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorMichael W. Kopcak Jr
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorJenny Liu
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorJi-Feng Chen
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorJose L. Navia
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA
Search for more papers by this authorWilliam A. Smith
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorCorresponding Author
Kiyotaka Fukamachi
Department of Biomedical Engineering, Lerner Research Institute; and
Dr. Kiyotaka Fukamachi, Department of Biomedical Engineering, ND20, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA. E-mail: [email protected]Search for more papers by this authorKeiji Kamohara
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorStephan Weber
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorRyan S. Klatte
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorViviane Luangphakdy
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorChristine R. Flick
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorYoshio Ootaki
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorMasatoshi Akiyama
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorFaruk Cingoz
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorChiyo Ootaki
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorMichael W. Kopcak Jr
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorJenny Liu
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorJi-Feng Chen
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorJose L. Navia
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA
Search for more papers by this authorWilliam A. Smith
Department of Biomedical Engineering, Lerner Research Institute; and
Search for more papers by this authorCorresponding Author
Kiyotaka Fukamachi
Department of Biomedical Engineering, Lerner Research Institute; and
Dr. Kiyotaka Fukamachi, Department of Biomedical Engineering, ND20, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA. E-mail: [email protected]Search for more papers by this authorAbstract
Abstract: To evaluate the effects of downsizing of the total artificial heart (TAH), we compared the anaerobic threshold (AT) values in calves with two different types of TAH (Cleveland Clinic–Nimbus TAH and the downsized MagScrew TAH). Exercise studies were performed using a treadmill in 12 calves. During the exercise, parameters to obtain the AT were measured. To evaluate the determinants of the AT, a linear regression analysis was performed between AT and potential variables. AT values from 29 studies revealed no significant differences between the two different TAHs, with no significant differences in hemodynamic or oxygen metabolic parameters. AT values correlated well with pump flow/body weight (Q) multiplied by the hemoglobin level, regardless of the TAH used. In conclusion, downsizing of the original TAH design did not reduce AT without any significant differences in hemodynamic or oxygen metabolic parameters during exercise in calves.
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