Volume 10, Issue 4 pp. 724-728
SHORT TAKE

The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity

Christine C. Yang

Christine C. Yang

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA

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Diana Chen

Diana Chen

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA

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Siu Sylvia Lee

Siu Sylvia Lee

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA

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Ludivine Walter

Ludivine Walter

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA

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First published: 04 April 2011
Citations: 45
Siu Sylvia Lee, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA. Tel.: +1 607 255 8015; fax: +1 607 255 6249; e-mail:[email protected]
Ludivine Walter, Ecole Normale Supérieure de Lyon, CNRS, Université de Lyon Claude Bernard, Molecular Biology of the Cell Laboratory/UMR5239, 46, Allée d’Italie, 69364 Lyon Cedex 07, France. Tel.: +33 4 72728663; fax: +33 4 72728080; e-mail:[email protected]

Summary

Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.

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