Journal of the European Academy of Dermatology and Venereology

Alopecia neoplastica due to metastatic breast carcinoma vs. extramammary Paget's disease: mimicry in epidermotropic carcinoma

Corresponding Author

N Haas

Department of Dermatology and Allergy, Charité, Humboldt-University Berlin, and

*Corresponding author, Department of Dermatology and Allergy, Charité, Humboldt–University Berlin, Germany, tel.: 49 30 450 518 124; fax: 49 30 450 518 915; E-mail: [email protected]Search for more papers by this author

St Hauptmann,

St Hauptmann

Institute of Pathology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

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N Haas,

Corresponding Author

N Haas

Department of Dermatology and Allergy, Charité, Humboldt-University Berlin, and

St Hauptmann,

St Hauptmann

Institute of Pathology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

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First published: 05 August 2004

https://doi.org/10.1111/j.1468-3083.2004.01034.x

Citations: 17

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ABSTRACT

Clinically similar skin diseases can exhibit phenotypic mimicry as demonstrated here for alopecia neoplastica. An 89-year-old female patient had been treated for scalp eczema for several years until biopsy revealed pagetoid carcinoma. Her clinical history showed a mastectomy 20 years ago. For that reason the differential diagnosis was extramammary Paget's disease or epidermotropic metastasis of the breast carcinoma. Immunohistochemistry revealed positivity of MUC1, indicating that the latter is the case.

References

1 Vilmer C, Trassard M. A case for diagnosis: cutaneous metastasis of breast carcinoma. Ann Dermatol Venereol 1993; 120: 561–562.
CAS PubMed Google Scholar
2 Miller JL. Metastatic carcinoma of the scalp. Arch Dermatol 1970; 102: 231.
10.1001/archderm.102.2.231b
PubMed Google Scholar
3 Requena L, Sanchez Yus E, Nunez C, White CR Jr, Sangueza OP. Epidermotropically metastatic breast carcinomas. Rare histopathologic variants mimicking melanoma and Paget's disease. Am J Dermatopathol 1996; 18: 385–395.
10.1097/00000372-199608000-00010
CAS PubMed Web of Science® Google Scholar
4 Kuan SF, Montag AG, Hart J, Krausz T, Recant W. Differential expression of mucin genes in mammary and extramammary Paget's disease. Am J Surg Pathol 2001; 25: 1469–1477.
10.1097/00000478-200112000-00001
CAS PubMed Web of Science® Google Scholar
5 Kondo Y, Kashima K, Daa T et al. The ectopic expression of gastric mucin in extramammary and mammary Paget's disease. Am J Surg Pathol 2002; 26: 617–623.
10.1097/00000478-200205000-00007
PubMed Web of Science® Google Scholar
6 Wick MR, Ockner DM, Mills SE, Ritter JH, Swanson PE. Homologous carcinomas of the breasts, skin, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma. Am J Clin Pathol 1998; 109: 75–84.
10.1093/ajcp/109.1.75
CAS PubMed Web of Science® Google Scholar
7 Mazoujian G, Margolis R. Immunohistochemistry of gross cystic disease fluid protein (GCDFP-15) in 65 benign sweat gland tumors of the skin. Am J Dermatopathol 1988; 10: 28–35.
10.1097/00000372-198802000-00004
CAS PubMed Web of Science® Google Scholar
8 Kohler S, Smoller BR. Gross cystic disease fluid protein-15 reactivity in extramammary Paget's disease with and without associated internal malignancy. Am J Dermatopathol 1996; 18: 118–123.
10.1097/00000372-199604000-00003
CAS PubMed Web of Science® Google Scholar
9 Ormsby AH, Snow JL, Su WP, Goellner JR. Differential expression of mucin genes in mammary and extramammary Paget's disease of cutaneous metastatic breast carcinoma. a statistical analysis of the utility of gross cystic disease fluid protein-15 and estrogen receptor protein. J Am Acad Dermatol 1995; 32: 711–716.
10.1016/0190-9622(95)91447-1
CAS PubMed Web of Science® Google Scholar

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Volume18, Issue6

November 2004

Pages 708-710

Alopecia neoplastica due to metastatic breast carcinoma vs. extramammary Paget's disease: mimicry in epidermotropic carcinoma

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Alopecia neoplastica due to metastatic breast carcinoma vs. extramammary Paget's disease: mimicry in epidermotropic carcinoma

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