Insulin sensitivity is impaired in patients with migraine
Corresponding Author
I Rainero
Neurology III – Headache Centre, Department of Neuroscience and
Dr Innocenzo Rainero, Neurology III – Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15–10126 Torino, Italy. Tel./Fax +39 011 6638510, e-mail [email protected]Search for more papers by this authorP Limone
Division of Endocrinology, Department of Internal Medicine, University of Turin, Italy
Search for more papers by this authorM Ferrero
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorW Valfrè
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorC Pelissetto
Division of Endocrinology, Department of Internal Medicine, University of Turin, Italy
Search for more papers by this authorE Rubino
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorS Gentile
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorR Lo Giudice
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorL Pinessi
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorCorresponding Author
I Rainero
Neurology III – Headache Centre, Department of Neuroscience and
Dr Innocenzo Rainero, Neurology III – Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15–10126 Torino, Italy. Tel./Fax +39 011 6638510, e-mail [email protected]Search for more papers by this authorP Limone
Division of Endocrinology, Department of Internal Medicine, University of Turin, Italy
Search for more papers by this authorM Ferrero
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorW Valfrè
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorC Pelissetto
Division of Endocrinology, Department of Internal Medicine, University of Turin, Italy
Search for more papers by this authorE Rubino
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorS Gentile
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorR Lo Giudice
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorL Pinessi
Neurology III – Headache Centre, Department of Neuroscience and
Search for more papers by this authorAbstract
Several studies have shown the presence of a comorbidity between migraine and vascular diseases, like hypertension and stroke. The mechanisms of this comorbidity are unknown. Impaired insulin sensitivity has recently emerged as a risk factor for hypertension and stroke. We evaluated insulin sensitivity in 30 young, nonobese, nondiabetic, normotensive migraine patients and in 15 healthy controls. During the OGTT, glucose plasma concentrations were significantly higher in migraineurs than in controls. Insulin sensitivity, as measured by ISI-stumvoll and OGIS-180 indexes, was significantly altered in migraine. Our data show that insulin sensitivity is impaired in migraine and suggest a role for insulin resistance in the comorbidity between migraine and vascular diseases.
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