Effect of a prebiotic-enriched phytocompound in improving ovalbumin allergenicity

Yussef METUGRIACHUK

Tsuchiya Medical Corporation Hospital and

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Juichiro TSUCHIYA,

Juichiro TSUCHIYA

Tsuchiya Medical Corporation Hospital and

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Francesco MAROTTA,

Francesco MAROTTA

Tsuchiya Medical Corporation Hospital and

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Sam KAWAKITA,

Sam KAWAKITA

Tsuchiya Medical Corporation Hospital and

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Ruichi OKURA,

Ruichi OKURA

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Olivia KUROI,

Olivia KUROI

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Emilio MINELLI,

Emilio MINELLI

Tsuchiya Medical Corporation Hospital and

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Yussef METUGRIACHUK,

Yussef METUGRIACHUK

Tsuchiya Medical Corporation Hospital and

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Juichiro TSUCHIYA,

Juichiro TSUCHIYA

Tsuchiya Medical Corporation Hospital and

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Francesco MAROTTA,

Francesco MAROTTA

Tsuchiya Medical Corporation Hospital and

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Sam KAWAKITA,

Sam KAWAKITA

Tsuchiya Medical Corporation Hospital and

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Ruichi OKURA,

Ruichi OKURA

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Olivia KUROI,

Olivia KUROI

Biokenkyusho Research Laboratory, Shizuoka, Japan; and WHO Center for Biotech and Natural Medicine, University of Milan, Italy

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Emilio MINELLI,

Emilio MINELLI

Tsuchiya Medical Corporation Hospital and

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First published: 17 October 2006

https://doi.org/10.1111/j.1443-9573.2006.00267.x

Citations: 5

Correspondence to: Francesco MAROTTA, Via Pisanello, 4, 20146 Milano, Italy. Email: [email protected]

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Abstract

OBJECTIVE: The aim of the present study was to test a prebiotic-phytotherapic compound in an experimental model of oral allergenicity.

METHODS: Antigen-specific immunoglobulin E (IgE) elevated mice were prepared by injecting them intraperitoneally with 10 µg of ovalbumin. Subsequently, the mice were exposed to ovalbumin solution intranasally and blood samples were obtained on weekly intervals for 4 weeks to measure serum-ovalbumin-specific IgE and total immunoglobulin G. Mice with high titers of ovalbumin-IgE were intragastrically administered with 0.3 mL of phosphate buffered solution containing either 20 mg of ovalbumin, the same solution with 5 mL of milk, or 20 mg milk added to prebiotic-phytocompound.

RESULTS: Ovalbumin administration caused a significant increase of plasma ovalbumin concentration in sensitized mice while prebiotic-phytocompound-supplemented mice showed a significantly reduced peak value (P < 0.05). Prebiotic-phytocompound added to milk exerted a significant effect in lowering the ovalbumin-IgE level and the total immunoglobulin G level as compared to control plain milk (P < 0.01).

CONCLUSION: This study provides a rationale basis for a feasible non-pharmacological therapeutic strategy in food allergen hypersensitivity syndromes.

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Volume7, Issue4

November 2006

Pages 206-210

Effect of a prebiotic-enriched phytocompound in improving ovalbumin allergenicity

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Effect of a prebiotic-enriched phytocompound in improving ovalbumin allergenicity

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