USEFULNESS OF DOUBLE BALLOON ENTEROSCOPY AND VIDEO CAPSULE ENDOSCOPY FOR THE DIAGNOSIS AND MANAGEMENT OF PRIMARY FOLLICULAR LYMPHOMA OF THE GASTROINTESTINAL TRACT IN ITS EARLY STAGES

Corresponding Author

Taiji Akamatsu

Department of Endoscopy, Shinshu University Hospital,

Taiji Akamatsu, Department of Endoscopy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto 390-8621, Japan. Email: [email protected]Search for more papers by this author

Yasunori Kaneko,

Yasunori Kaneko

Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine,

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Hiroyoshi Ota,

Hiroyoshi Ota

Department of Biomedical Sciences, School of Health Sciences, Shinshu University School of Medicine and

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Hideharu Miyabayashi,

Hideharu Miyabayashi

Internal Medicine, National Hospital Organization, Matsumoto Hospital, Matsumoto, Japan

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Norikazu Arakura,

Norikazu Arakura

Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine,

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Eiji Tanaka,

Eiji Tanaka

Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine,

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Taiji Akamatsu,

Corresponding Author

Taiji Akamatsu

Department of Endoscopy, Shinshu University Hospital,

Taiji Akamatsu, Department of Endoscopy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto 390-8621, Japan. Email: [email protected]Search for more papers by this author

Yasunori Kaneko,

Yasunori Kaneko

Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine,

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Hiroyoshi Ota,

Hiroyoshi Ota

Department of Biomedical Sciences, School of Health Sciences, Shinshu University School of Medicine and

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Hideharu Miyabayashi,

Hideharu Miyabayashi

Internal Medicine, National Hospital Organization, Matsumoto Hospital, Matsumoto, Japan

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Norikazu Arakura,

Norikazu Arakura

Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine,

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Eiji Tanaka,

Eiji Tanaka

Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine,

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First published: 15 December 2009

https://doi.org/10.1111/j.1443-1661.2009.00915.x

Citations: 21

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Abstract

Aim: The aim of this study is to evaluate the usefulness of double balloon enteroscopy (DBE) and video capsule endoscopy (VCE) in patients with primary follicular lymphoma (FL) of the gastrointestinal (GI) tract. Furthermore, we estimate the effectiveness of chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone) including rituximab for them.

Methods: Thirteen consecutive patients who were diagnosed of having FL in the duodenum between July 2005 and September 2008 were studied. All patients were given the conventional staging examinations, including total enteroscopy using DBE and/or VCE procedures. Chemotherapy was performed after written informed consent. Response assessment was performed every 6-12 months. The median follow-up period was 30.2 months.

Results: FL was diagnosed in each patient as low grade (grade 1, n = 7; 2, n = 6) and, in all but 4 patients, localized lymphoma (stage I, n = 8; II₁, n = 1; II₂, n = 4). DBE revealed multifocal lesions in the jejunum in 10 of the patients, and in the ileum in 6. VCE showed similar findings in the jejunum in the recent 2 patients. Eleven of 13 patients finally received chemotherapy, and all of them achieved complete regression. They showed no evidence of recurrence after that.

Conclusion: Total examination of the small intestine using DBE should be performed before treatment to choose a suitable treatment procedure for primary FL of the GI tract. On the other hand, VCE is useful for screening and following the small intestine in the patients with it. Chemotherapy is effective to achieve complete regression of primary FL of the GI tract.

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USEFULNESS OF DOUBLE BALLOON ENTEROSCOPY AND VIDEO CAPSULE ENDOSCOPY FOR THE DIAGNOSIS AND MANAGEMENT OF PRIMARY FOLLICULAR LYMPHOMA OF THE GASTROINTESTINAL TRACT IN ITS EARLY STAGES

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USEFULNESS OF DOUBLE BALLOON ENTEROSCOPY AND VIDEO CAPSULE ENDOSCOPY FOR THE DIAGNOSIS AND MANAGEMENT OF PRIMARY FOLLICULAR LYMPHOMA OF THE GASTROINTESTINAL TRACT IN ITS EARLY STAGES

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