Volume 54, Issue 1 pp. 76-80

Cord serum adiponectin is positively related to postnatal body mass index gain

Yuya Nakano

Corresponding Author

Yuya Nakano

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

Yuya Nakano, MD, Department of Pediatrics, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. Email: [email protected]Search for more papers by this author
Kazuo Itabashi

Kazuo Itabashi

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

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Keiko Nagahara

Keiko Nagahara

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

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Motoichiro Sakurai

Motoichiro Sakurai

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

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Madoka Aizawa

Madoka Aizawa

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

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Kazushige Dobashi

Kazushige Dobashi

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

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Katsumi Mizuno

Katsumi Mizuno

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

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Daisuke Tanaka

Daisuke Tanaka

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

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First published: 24 November 2011
Citations: 8

Abstract

Background: The roles of adiponectin and leptin in the early stages of life are poorly understood. We previously studied longitudinal changes in these adipocytokines from birth to 12 months of age. The aim of this investigation was to evaluate the correlation between cord serum adipocytokine levels and postnatal growth by 3 years of age.

Methods: A questionnaire was sent to obtain the general physical measurements of 3-year-olds from 56 healthy newborn infants born at a gestational age of 35 weeks or more; 45 valid responses were obtained. The correlations between variables, including cord serum adipocytokine levels at birth and general physical measurements at 3 years, were investigated.

Results: Body mass index (BMI) Z-score gain from birth to 3 years was negatively correlated with birthweight SD scores (β=−0.395, P= 0.019) and gestational age (β=−0.557, P= 0.016), and positively correlated with cord serum adiponectin levels (β= 0.253, P= 0.043). BMI Z-score gain from birth to 6 months was negatively correlated with only birthweight SD score (β=−0.442, P= 0.017). Cord serum leptin levels were not a significant predictor of BMI Z-scores gain in our subjects. BMI Z-scores at 6 months, 12 months, and 3 years of age were not related to cord serum adiponectin or leptin levels.

Conclusions: Birthweight SD score, gestational age, and cord serum adiponectin levels are significant predictors of BMI Z-score gain from birth to 3 years of age in Japanese infants.

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