Asst. Prof. Dr Evren Köse, İnonu University Medical Faculty, Department of Anatomy, 44280 Malatya, Türkey
Tel.: +90 422 341 06 60 (1272);
Fax: +90 422 341 00 36;
E-mail: [email protected]

Read the full text

About

PDF

Tools

Share a link

Email
Wechat
Bluesky

Summary

In this experimental study, harmful effects of formaldehyde (FA) inhalation on sperm concentration, sperm quality, serum testosterone levels and the rat testes were investigated. In addition, the possible protective effects of rose oil against to these harmful effects were evaluated. For this purpose, 21 albino-Wistar rats were used. The rats in Group I were used as control group. When the rats of Group II were exposed FA (10 ppm/1 h) for 35 days, the rats of Group III inhalated rose oil (1 ml/1 h) after FA. The epididymal tissues were taken for sperm analysing and the testes were removed for histological examination. In addition, testosterone levels were determined from the blood samples. Although the testosterone levels, the epididymal sperm concentration, and the progressive sperm motility significantly decreased, the abnormal sperm rate significantly increased in the Group II when compared to Group I. In the Group III, these damages were seen less. When the rats in the Group II compared with the control group, there were serious histological damages. In the Group III, it was determined that the histological changes were less than group II. It can be expressed that serious damages occurred via formaldehyde exposure in male reproductive system and that the rose oil had protective effects against these damages.

References

Almeida R, Simone CM, Faturib CB, Catallanib B, Leite JR (2004) Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze test in rats. Pharmacol Biochem Behav 77: 361–364.
10.1016/j.pbb.2003.11.004
CAS PubMed Web of Science® Google Scholar
Altıntaş A (2007) Gül Gülsuyu Tarihte, Tedavide ve Gelenekteki Yeri (Rose, Rosewater, In the Past, Therapy and Traditional Application), 1st edn. Tempo Matbaacılık, İstanbul.
Google Scholar
Basim E, Basim H (2003) Antibacterial activity of Rosa damascena essential oil. Fitoterapia 74: 394–396.
10.1016/S0367-326X(03)00044-3
CAS PubMed Web of Science® Google Scholar
Boskabady MH, Kaini S, Rakhshandah H (2006) Relaxant effects of Rosa damascena on guinea pig tracheal chains and its possible mechanism(s). J Ethnopharmacol 106: 377–382.
10.1016/j.jep.2006.01.013
CAS PubMed Web of Science® Google Scholar
Bradley BF, Starkey NJ, Brown SL, Lea RW (2007) The effects of prolonged rose odor inhalation in two animal models of anxiety. Physiol Behav 92: 931–938.
10.1016/j.physbeh.2007.06.023
CAS PubMed Web of Science® Google Scholar
Chowdhury AR, Gautam AK, Patel KG, Trivedi HS (1992) Steroidogenic inhibition in testicular tissue of formaldehyde exposed rats. Indian J Physiol Pharmacol 36: 162–168.
CAS PubMed Google Scholar
Cohen BI, Pagnillo MK, Musikant BL, Deutsch AS (1998) Formaldehyde evaluation from endodontic materials. Oral Health 88: 37–39.
CAS PubMed Google Scholar
Collins JJ, Ness R, Tyl RW, Krivanek N, Esmen NA, Hall TA (2001) A review of adverse pregnancy outcomes and formaldehyde exposure in human and animal studies. Regul Toxicol Pharmacol 34: 17–34.
10.1006/rtph.2001.1486
CAS PubMed Web of Science® Google Scholar
Ergen A, Ozkan G, Bicer A (2003) The effect of pressure on the extraction of essential oil from flowers of lavender plants with supercritical CO₂. Gazi Üniversitesi Journal of Science 17: 717–723.
Google Scholar
Golalipour MJ, Azarhoush R, Ghafari S, Gharravi AM, Fazeli SA, Davarian A (2007) Formaldehyde exposure induces histopathological and morphometric changes in the rat testis. Folia Morphol (Warsz) 66: 167–171.
CAS PubMed Google Scholar
Heck H, Casanova M (1999) Pharmacodynamics of formaldehyde: Applications of a model for the arrest of DNA replication by DNA-protein cross-links. Toxicol Appl Pharmacol 160: 86–100.
10.1006/taap.1999.8764
CAS PubMed Web of Science® Google Scholar
Henkel R, Maass G, Schuppe HC, Jung A, Schubert J, Schill WB (2005) Molecular aspects of declining sperm motility in older men. Fertil Steril 84: 1430–1437.
10.1016/j.fertnstert.2005.05.020
CAS PubMed Web of Science® Google Scholar
Joensen UN, Jørgensen N, Rajpert-De Meyts E, Skakkebaek NE (2008) Testicular dysgenesis syndrome and Leydig cell function. Basic Clin Pharmacol Toxicol 102: 155–161.
10.1111/j.1742-7843.2007.00197.x
CAS PubMed Web of Science® Google Scholar
Khanzadeh FA, Vaquerano MU, Khanzadeh MA, Bisesi MS (1994) Formaldehyde exposure, acute pulmoner response and exposure control options in a gross anatomy laboratory. Am J Indust Med 26: 61–68.
10.1002/ajim.4700260106
Web of Science® Google Scholar
Komiya M, Takeuchi T, Harada E (2006) Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behav Brain Res 172: 240–249.
10.1016/j.bbr.2006.05.006
CAS PubMed Web of Science® Google Scholar
Kose E, Sarsilmaz M, Ogeturk M, Kus I, Kavakli A, Zararsiz I (2007) The role of rose essential oil aroma on the learning behaviorus: an experimental study. Fırat Medical Journal 12: 159–162.
Google Scholar
Kriebel D, Myers D, Cheng M, Woskie S, Cocanour B. (2001) Short term effect of formaldehyde on peak expiratory flow and irritant symptoms. Arch Environ Health 56: 11–18.
10.1080/00039890109604049
CAS PubMed Web of Science® Google Scholar
Kurkcuoglu M, Baser KHC (2003) Studies on Turkish rose concrete, “absolute and hydrosol”. Chem Nat Comp 39: 457–464.
10.1023/B:CONC.0000011120.71479.7f
CAS Web of Science® Google Scholar
Mahmood N, Piacente S, Pizza C, Burke A, Khan AI, Hay AJ (1996) The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa Damascena. Biochem Biophys Res Commun 229: 73–79.
10.1006/bbrc.1996.1759
CAS PubMed Web of Science® Google Scholar
Majumder PK, Kumar VL (1995) Inhibitory effects of formaldehyde on the reproductive system of male rats. Indian J Physiol Pharmacol 39: 80–82.
CAS PubMed Google Scholar
Marsh GM, Youk AO, Buchanich JM, Erdal S, Esmen NA (2007) Work in the metal industry and nasopharyngeal cancer mortality among formaldehyde-exposed workers. Regul Toxicol Pharmacol 48: 308–319.
10.1016/j.yrtph.2007.04.006
CAS PubMed Web of Science® Google Scholar
Odeigah PG (1997) Sperm head abnormalities and dominant lethal effects of formaldehyde in albino rats. Mutat Res 389: 141–148.
10.1016/S1383-5718(96)00136-2
CAS PubMed Web of Science® Google Scholar
Ozen OA, Akpolat N, Songur A, Kus I, Zararsiz I, Ozaçmak VH, Sarsilmaz M (2005) Effect of formaldehyde inhalation on Hsp70 in seminiferous tubules of rat testes: an immunohistochemical study. Toxicol Ind Health 21: 249–254.
10.1191/0748233705th235oa
CAS PubMed Web of Science® Google Scholar
Ozen OA, Kus MA, Kus I, Alkoc OA, Songur A (2008) Protective effects of melatonin against formaldehyde-induced oxidative damage and apoptosis in rat testes: an immunohistochemical and biochemical study. Syst Biol Reprod Med 54: 169–176.
10.1080/19396360802422402
CAS PubMed Web of Science® Google Scholar
Roberto G, Maratta MT (2000) Antioxidant activity of selected essential oil components in two lipid model systems. Food Chem 69: 167–174.
10.1016/S0308-8146(99)00247-2
Web of Science® Google Scholar
Sarsilmaz M, Ozen OA (2000) The histopathologic changes on leydig cells of the rats ınhaled formaldehyde along subchronic period. Fırat Medical Journal 2: 1–5.
Google Scholar
Sarsilmaz M, Kaplan S, Songur A, Colakoglu S, Aslan H, Tunc AT, Ozen OA, Turgut M, Bas O (2007) Effects of postnatal formaldehyde exposure on pyramidal cell number, volume of cell layer in hippocampus and hemisphere in the rat: a stereological study. Brain Res 1145: 157–167.
10.1016/j.brainres.2007.01.139
CAS PubMed Web of Science® Google Scholar
Sonmez M, Turk G, Yuce A (2005) The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels in male wistar rats. Theriogenology 63: 2063–2072.
10.1016/j.theriogenology.2004.10.003
CAS PubMed Web of Science® Google Scholar
Sonmez M, Yuce A, Turk G (2007) The protective effects of melatonin and vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats. Reprod Toxicol 23: 226–231.
10.1016/j.reprotox.2006.11.003
CAS PubMed Web of Science® Google Scholar
Tang M, Xie Y, Yi Y, Wang W (2003) Effects of formaldehyde on germ cells of male mice. Wei Sheng Yan Jiu 32: 544–548.
CAS PubMed Google Scholar
Taskinen H, Kyyronen P, Hemminki K, Hoikkala M, Lajunen K, Lindbohm ML (1994) Laboratory work and pregnancy outcome. J Occup Med 36: 311–319.
10.1097/00043764-199403000-00008
CAS PubMed Google Scholar
Turk G, Atessahin A, Sonmez M, Yuce A, Ceribasi AO (2007) Lycopene protects against cyclosporine A-induced testicular toxicity in rats. Theriogenology 67: 778–785.
10.1016/j.theriogenology.2006.10.013
CAS PubMed Web of Science® Google Scholar
Usanmaz SE, Akarsu ES, Vural N (2002) Neurotoxic effects of acute and subacute formaldehyde exposures in mice. Environ Toxicol Pharmacol 11: 93–100.
10.1016/S1382-6689(01)00109-0
CAS PubMed Web of Science® Google Scholar
Wei A, Shibamoto T (2007) Antioxidant activities and volatile constituents of various essential oils. J Agric Food Chem 55: 1737–1742.
10.1021/jf062959x
CAS PubMed Web of Science® Google Scholar
Zararsız İ, Kus İ, Colakoglu N, Pekmez H, Yılmaz HR, Sarsilmaz M (2004) Protective effects of melatonin hormone against exposure of formaldehyde-induced oxidative damage in lung of rats: light microscopic and biochemical study. Van Med J 11: 105–112.
Google Scholar
Zhou DX, Qiu SD, Zhang J, Wang ZY (2006) Reproductive toxicity of formaldehyde to adult male rats and the functional mechanism concerned. Sichuan Da Xue Xue Bao Yi Xue Ban 37: 566–569.
CAS PubMed Google Scholar

Citing Literature

All articles

Rose oil inhalation protects against formaldehyde-induced testicular damage in rats

Summary

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Rose oil inhalation protects against formaldehyde-induced testicular damage in rats

Summary

References

Citing Literature

References

Related

Information