Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes
Hongtao Ye
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorDina Halai
Cancer Institute, UCL, London, UK
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorBernadine D Idowu
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorRoberto Tirabosco
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorAdrienne M Flanagan
Cancer Institute, UCL, London, UK
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorHongtao Ye
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorDina Halai
Cancer Institute, UCL, London, UK
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorBernadine D Idowu
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorRoberto Tirabosco
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this authorAdrienne M Flanagan
Cancer Institute, UCL, London, UK
Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Search for more papers by this author
References
- 1 Tovar C, Rosinski J, Filipovic Z et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc. Natl Acad. Sci. USA 2006; 103; 1888–1893.
- 2 Yoshida A, Ushiku T, Motoi T et al. Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Mod. Pathol. 2010; 23; 1279–1288.
- 3 Gamberi G, Ragazzini P, Benassi MS et al. Analysis of 12q13-15 genes in parosteal osteosarcoma. Clin. Orthop. Relat. Res. 2000; 377; 195–204.
- 4 Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J. Biol. Chem. 2006; 281; 33030–33035.
- 5 Mejia-Guerrero S, Quejada M, Gokgoz N et al. Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Genes Chromosom. Cancer 2010; 49; 518–525.
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