Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas
G Alipov
Tissue and Histopathology Section, Division of Scientific Data Registry
Search for more papers by this authorT Nakayama
Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
Search for more papers by this authorM Ito
Department of Pathology, National Nagasaki Medical Center, Omura
Search for more papers by this authorK Kawai
Department of Pathology, Nagasaki Municipal Hospital, Nagasaki,
Search for more papers by this authorS Naito
Department of Pathology, Ureshino National Hospital, Saga, Japan
Search for more papers by this authorM Nakashima
Tissue and Histopathology Section, Division of Scientific Data Registry
Search for more papers by this authorD Niino
Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
Search for more papers by this authorI Sekine
Tissue and Histopathology Section, Division of Scientific Data Registry
Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
Search for more papers by this authorG Alipov
Tissue and Histopathology Section, Division of Scientific Data Registry
Search for more papers by this authorT Nakayama
Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
Search for more papers by this authorM Ito
Department of Pathology, National Nagasaki Medical Center, Omura
Search for more papers by this authorK Kawai
Department of Pathology, Nagasaki Municipal Hospital, Nagasaki,
Search for more papers by this authorS Naito
Department of Pathology, Ureshino National Hospital, Saga, Japan
Search for more papers by this authorM Nakashima
Tissue and Histopathology Section, Division of Scientific Data Registry
Search for more papers by this authorD Niino
Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
Search for more papers by this authorI Sekine
Tissue and Histopathology Section, Division of Scientific Data Registry
Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
Search for more papers by this authorAbstract
Aims : The high incidence of clinically diagnosed prostatic cancer is exceeded by the frequency of tumours detected at autopsy. The Ets-1 proto-oncogene is expressed by a variety of malignant and normal tissues. Therefore, in this study, expression of Ets-1 protein was investigated in ‘latent’ prostatic cancer detected at autopsy, compared with benign prostatic hyperplasia, normal prostatic tissues and clinical prostatic cancer.
Methods and results : Using immunohistochemistry, we analysed Ets-1 expression in 95 prostatic specimens including 19 cases of latent prostatic carcinoma (LPC) and 55 cases of clinical prostatic carcinoma (CPC), 11 cases of benign prostatic hyperplasia (BPH) and 10 cases of normal prostate (NP). Differences in the incidence of LPC and CPC suggest different courses for the biological progression of prostatic cancer. There was a significant difference in the degree of Ets-1 expression in CPC and LPC (P < 0.05). Ets-1 was not expressed in BPH and NP, but in malignant cases (57 of 74; 77.0%) commonly demonstrated immunoreactivity in the tumour cells. In our study the expression of Ets-1 between benign and malignant, and well, moderately and poorly differentiated adenocarcinomas of prostatic cancer showed significant differences. The presence of Ets-1 mRNA was confirmed by in-situ hybridization in human prostatic tissues.
Conclusion : Our results suggest that Ets-1 might play an important role in carcinogenesis and/or the progression of human prostatic carcinomas.
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